Evidence map›Paper›PMID 41606329›Full record

ArticleNature2026

A prophage-encoded abortive infection protein preserves host and prophage spread.

Molly R Sargen, Sadie P Antine, Grzegorz J Grabe, Gabriella Antonellis, Adelyn E Ragucci, Yao Li, Philip J Kranzusch, Sophie Helaine

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. mBio · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Molly R SargenDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4916-0577
Sadie P AntineDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0843-2986
Grzegorz J GrabeIntercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Gdansk, Poland.ORCID 0000-0002-0419-491X
Gabriella AntonellisDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID 0009-0006-4495-4772
Adelyn E RagucciDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Yao LiDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Sophie HelaineDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. Sophie_helaine@hms.harvard.edu.ORCID 0000-0002-9877-4180

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Martin Fuchs · 2019 to 2026
$38.6M
The physiological activation and consequences of Toxin-Antitoxin systems in SalmonellaR01AI155552 · NIAID · HARVARD MEDICAL SCHOOL · PI HELAINE, SOPHIE · 2021 to 2025
$2.5M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
The Dynamics of DNA in Salmonella Persisters in MacrophagesF31AI176589 · NIAID · HARVARD MEDICAL SCHOOL · PI SARGEN, MOLLY RENEE · 2023 to 2025
$87k
NIAID NIH HHS F31 AI176589NIAID NIH HHS R01 AI155552NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

Most bacterial pathogens are polylysogens, harbouring multiple vertically transmitted prophages

Indexed as

ProphagesSalmonella typhimuriumViral ProteinsModels, MolecularRNA, TransferSiphoviridaeVirus ReplicationRNA, TransferViral Proteins

Identifiers

PMID41606329
PMCPMC13043305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.