Evidence map›Paper›PMID 41606314›Full record

ArticleNature2026

Structure and mechanism of the human bile acid transporter OSTα-OSTβ.

Ke Wang, Junping Fan, Huiwen Chen, Bo Huang, Cheng Chi, Rui Yan, Di Wu, Feng Zhou, Wenhua Zhang, Juquan Jiang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ke Wang *Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Junping Fan *Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. fanjp@pku.edu.cn.ORCID 0000-0002-2615-8098
Huiwen Chen *Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Bo Huang *Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing, China.ORCID 0000-0003-3822-9110
Cheng Chi *Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Weifang, China.
Rui YanBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.ORCID 0009-0008-5896-8256
Di WuBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0003-2271-4963
Feng ZhouBeijing StoneWise Technology, Beijing, China.ORCID 0000-0001-9040-1796
Wenhua ZhangJiangxi Institute of Respiratory Disease, First Affiliated Hospital; School of Basic Medical Sciences; Institute of Biomedical Innovation, Jiangxi Province Key Laboratory of Brain Science and Brain Health, Jiangxi Medical College, Nanchang University, Nanchang, China.
Juquan JiangDepartment of Microbiology and Biotechnology, College of Life Sciences, Northeast Agricultural University, Harbin, China. jjqdainty@163.com.ORCID 0000-0001-8121-4518
Xiaoguang LeiBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. xglei@pku.edu.cn.ORCID 0000-0002-0380-8035
Daohua JiangBeijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, China. jiangdh@iphy.ac.cn.ORCID 0000-0002-4397-5807

Funding

Beijing National Laboratory for Molecular SciencesInnovative Drug Research and Development National Science and Technology Major ProjectMajor Program of the Chinese Academy of SciencesNational Natural Science Foundation of China
6 · The paper itself

Abstract

Bile acids (BAs) are crucial amphipathic surfactants that function as multifaceted regulators in various physiological processes, including nutrient absorption and distribution, lipid metabolism and inflammation

Indexed as

Bile Acids and SaltsCryoelectron MicroscopyMembrane Transport ProteinsCholesterolHumansModels, MolecularProtein MultimerizationReceptors, G-Protein-CoupledBile Acids and SaltsCholesterolMembrane Transport Proteinsorganic solute transporter alpha, humanReceptors, G-Protein-CoupledSLC51B protein, human

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.