Evidence map›Paper›PMID 41606290›Full record

ArticleBritish journal of haematology2026

Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia.

Eva Crespo-García, Carlos Quero-Dotor, Aleix Noguera-Castells, Laia Sancho-Vila, Laura Martinez-Verbo, Manel Esteller

Abstract read
In one paragraph

Article in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eva Crespo-GarcíaCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Carlos Quero-DotorCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Aleix Noguera-CastellsCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.ORCID https://orcid.org/0000-0001-7436-6513
Laia Sancho-VilaCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
Laura Martinez-VerboCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.ORCID https://orcid.org/0000-0003-0817-3056
Manel EstellerCancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.ORCID https://orcid.org/0000-0003-4490-6093

Funding

Cellex Foundation CEL007'la Caixa' Foundation LCF/PR/HR22/00732Ministry of Science, Innovation and Universities, Spain FPU22/01655Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia 2021 SGR01494The Agencia Estatal de Investigacion, Spain CPP2023-010525The Agencia Estatal de Investigacion, Spain PID2021-125282OB-I00The Agencia Estatal de Investigacion, Spain PID2024-159192OB-I00
6 · The paper itself

Abstract

We show how the loss of activity of the translation initiation factor EIF5A2-either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post-translational modification-induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.

Indexed as

Antineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicEpigenesis, GeneticGene SilencingLeukemia, Myeloid, AcutePeptide Initiation FactorsRNA-Binding ProteinsSulfonamidesCell Line, TumorDNA MethylationDrug Resistance, NeoplasmEukaryotic Translation Initiation Factor 5AHumansAntineoplastic AgentsBridged Bicyclo Compounds, HeterocyclicEukaryotic Translation Initiation Factor 5APeptide Initiation FactorsRNA-Binding ProteinsSulfonamidesvenetoclaxacute myeloid leukemiaDNA methylationEpigeneticsvenetoclax

Identifiers

PMID41606290
PMCPMC13071488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.