Evidence map›Paper›PMID 41606281›Full record

ReviewAdvances in experimental medicine and biology2026

Structure-Function Studies of Pentameric Ligand-Gated Ion Channels: Combining Experimental and Computational Approaches.

Wayland W L Cheng, Mark J Arcario

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. 4-Phenylbutyrate Rescue inbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Wayland W L ChengDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA. wayland.cheng@wustl.edu.ORCID https://orcid.org/0000-0002-9529-9820
Mark J ArcarioDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.

Funding

Lipid Modulation of Ligand-Gated Ion ChannelsR35GM137957 · NIGMS · WASHINGTON UNIVERSITY · PI Wayland Wing-Lun Cheng · 2020 to 2026
$2.9M
NIGMS NIH HHS R35 GM137957
6 · The paper itself

Abstract

Pentameric ligand-gated ion channels (pLGICs) are a family of cation- and anion-selective channels that mediate fast synaptic transmission and regulate excitability in the nervous system. They include the GABA(A) receptor, nicotinic acetylcholine receptor (nAChR), glycine receptor (GlyR), and serotonin receptor (5-HT3

Indexed as

Ion Channel GatingLigand-Gated Ion ChannelsAnimalsCryoelectron MicroscopyHumansLigandsModels, MolecularProtein ConformationReceptors, GABA-AReceptors, GlycineReceptors, NicotinicReceptors, Serotonin, 5-HT3Structure-Activity RelationshipLigand-Gated Ion ChannelsLigandsReceptors, GABA-AReceptors, GlycineReceptors, NicotinicReceptors, Serotonin, 5-HT3ConductanceGatingIon channelLigandLipids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.