ReviewAdvances in experimental medicine and biology2026
Mutagenesis-Centered Integrative Approaches for Identifying Binding Sites in Ion Channels and Uncovering Modulatory Mechanisms.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Recent advances in structural techniques have provided unprecedented insights into protein structure and function. Yet, obtaining insights into the structure and function of transmembrane proteins, whether alone or in complex with modulators or other proteins, remains challenging. The aim of this chapter is to demonstrate how mutagenesis studies, in conjunction with sequence, structural, and computational information, can assist in identifying binding regions in ion channels and provide mechanistic insights into their modulation. The examples presented comprise various potassium channels and include the identification of binding sites for ions such as sodium and for lipids, including PI(4,5)P
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