Evidence map›Paper›PMID 41606214›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.

Helen Lavretsky, Sahib Khalsa, Hanadi Ajam Oughli, Agustin Ibanez, Josefina Cruzat, Emmeline Edwards, Paul Newhouse, Claudio L A Bassetti, Indrit Begue, Andrea S Winkler and 2 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Neuropsychiatric illness in the later years of life: summary and synthesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Helen LavretskyDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA. hlavretsky@mednet.ucla.edu.ORCID http://orcid.org/0000-0001-9990-5085
Sahib KhalsaDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2124-8585
Hanadi Ajam OughliDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Agustin IbanezLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.ORCID http://orcid.org/0000-0001-6758-5101
Josefina CruzatLatin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile.
Emmeline EdwardsWorld Women in Neuroscience, 501(c)(3); retired as of 5/31/2025, National Center for Complementary and Integrative Health (until May 27, 2025), Ellicott city, MD, USA.
Paul NewhouseDepartment of Psychiatry and Behavioral Sciences, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-9298-7185
Claudio L A BassettiDepartment of Neurology, Medical Faculty, University of Bern, Inselspital, Bern, Switzerland.
Indrit BegueDepartment of Psychiatry, Laboratory for Neuroimaging and Translational Psychiatry, University of Geneva and University Hospitals of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0000-0001-5350-4454
Andrea S WinklerDepartment of Neurology, TUM University Hospital, and Center for Global Health, TUM School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Dilip V JesteSocial Determinants of Health Network, La Jolla, CA, USA.
Harris A EyreDepartment of Psychological Sciences, Office of Innovation, Center for Health, Baker Institute for Public Policy, School of Engineering, Rice University, Houston, TX, USA.ORCID http://orcid.org/0000-0003-4827-8258

Funding

Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
NCCIH NIH HHS K24 AT009198U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH) AT009198
6 · The paper itself

Abstract

Global population aging and increased chronic stress due to numerous mass disasters including those related to pandemics, climate change, war, displacement, and political unrest all challenge our collective resilience, with a growing burden of late-life neuropsychiatric and neurodegenerative disorders placing unprecedented demands on health and social systems worldwide. With these considerations in mind, understanding and promoting brain health is becoming a priority for the prevention of neuropsychiatric disorders across the lifespan. Brain health represents a dynamic balance of neural, cognitive, and emotional processes that determine resilience to neuropsychiatric illness. In later life, this balance becomes particularly critical as neurobiological and psychosocial stressors converge to shape trajectories of neuropsychiatric and neurodegenerative disorders. This review synthesizes current evidence on the determinants of brain health in aging, emphasizing resilience as a modifiable pathway linking neuropsychiatric illness risk and prevention. We integrate insights from neuroscience, lifestyle medicine, geroscience, and social determinants of health to emphasize the value of a whole-person, life-course approach. Particular attention is given to the interplay between stress physiology, interoceptive regulation, emotional resilience, and cognitive and brain reserve across the aging continuum. Emerging frameworks including brain clocks, precision biomarkers, digital phenotyping, and artificial intelligence, are considered as tools for risk stratification, early detection, and personalized intervention. By linking resilience mechanisms to measurable biological indices, we argue for the integration of neurobiological, psychological, behavioral, and sociocultural domains to inform next-generation strategies in neuropsychopharmacology, prevention science, and the promotion of healthy brain aging.

Identifiers

PMID41606214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.