Evidence map›Paper›PMID 41605957›Full record

ArticleNPJ systems biology and applications2026

Dynamical network analysis reveals long-range residue couplings at the pMHC interface underlying enhanced immunogenicity.

Tom Resink, Benedetta Maria Sala, Renhua Sun, Xiao Han, Evren Alici, Flavio Salazar-Onfray, Tatyana Sandalova, Cheng Zhang, Hans-Gustaf Ljunggren, Adnane Achour

Abstract read
In one paragraph

Article in NPJ systems biology and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tom ResinkScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden. tom.resink@ki.se.
Benedetta Maria SalaScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden.
Renhua SunScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden.
Xiao HanScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden.
Evren AliciCentre for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institute, Huddinge, Sweden.
Flavio Salazar-OnfrayScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden.
Tatyana SandalovaScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden.
Cheng ZhangDivision of Systems Biology, Department of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.
Hans-Gustaf LjunggrenCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institute, Huddinge, Sweden.
Adnane AchourScience for Life Laboratory, Department of Medicine, Karolinska Institute, Solna, Sweden. adnane.achour@ki.se.

Funding

Cancerfonden 24 3775 Pj 01 HInsamlingsstiftelsen Cancer- och Allergifonden 10399Stiftelsen Konung Gustaf V:s Jubileumsfond 244092Vetenskapsrådet 2021-05061Vinnova NextGenNK Competence Center 2024-03709
6 · The paper itself

Abstract

The interaction between a class I peptide-major histocompatibility complex (pMHC) and a T cell receptor (TCR) plays a central role in the elicitation of CD8

Indexed as

Histocompatibility Antigens Class IMajor Histocompatibility ComplexCD8-Positive T-LymphocytesHumansImmunoinformaticsMolecular Dynamics SimulationPeptidesReceptors, Antigen, T-CellHistocompatibility Antigens Class IPeptidesReceptors, Antigen, T-Cell

Identifiers

PMID41605957
PMCPMC12855856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.