Evidence map›Paper›PMID 41605918›Full record

ArticleNature communications2026

Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques.

Karla K Ausderau, Ben Boerigter, Elaina R Razo, Jake Gutkes, Nicholas P Krabbe, Ann M Mitzey, Shannon Walsh, Viktorie Menna, John R Drew, Sabrina Kabakov and 17 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Karla K AusderauDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-0799-1022
Ben BoerigterDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
Elaina R RazoDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Jake GutkesDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
Nicholas P KrabbeDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5511-0915
Ann M MitzeyDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Shannon WalshDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
Viktorie MennaDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
John R DrewDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.
Sabrina KabakovDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-4852-9360
Finn EckesDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Rachel V SpantonDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-3987-2503
Anika ShahDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Angelica SunDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Alex KatzDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-6941-2108
Charlene KimDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-1205-4535
Amy HartmanDepartment of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-3635-8883
Andrea M WeilerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Carol RasmussenDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.
T Michael NorkDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-0687-373X
Puja BasuWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-4051-7998
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-4862-7289
James Ver HoeveDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0003-3541-7589
Saverio CapuanoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Matthew T AliotaDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, St. Paul, MN, USA.ORCID http://orcid.org/0000-0002-6902-9149
Thomas C FriedrichWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-9831-6895
Emma L MohrDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. emohr2@wisc.edu.ORCID http://orcid.org/0000-0003-0742-305X

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
Zika virus pathophysiology during pregnancyP01AI132132 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$10.2M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Early neural predictors and neuropathogenesis of sensorimotor neurodevelopmental deficits in macaque infants exposed to Zika virus in uteroR01AI153130 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI AUSDERAU, KARLA KAYE, MOHR, EMMA L · 2020 to 2024
$3.8M
NEI NIH HHS P30 EY016665NIAID NIH HHS P01 AI132132NIAID NIH HHS R01 AI153130NICHD NIH HHS P50 HD105353NIH HHS P51 OD011106U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) P50HD105353U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) P30EY016665U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI153130
6 · The paper itself

Abstract

Prenatal Zika virus (ZIKV) exposure can result in outcomes ranging from severe birth defects to subtle developmental delays, yet the underlying mechanisms remain unclear. Using a translational rhesus macaque model, we assess visual, auditory, and neurodevelopmental outcomes through 12 months of age following first-trimester ZIKV inoculation. Pregnant macaques, either flavivirus-naive or with prior dengue virus (DENV) exposure, are inoculated with Asian or African ZIKV lineages. Maternal viremia duration, placental viral burden, and neutralizing antibody titers vary but are not associated with developmental outcomes. At 12 months, ZIKV-exposed infants exhibit altered maternal attachment behaviors and reduced inhibition toward novel sensory stimuli. Visual evoked potentials are impaired at 3 months but normalize by 12 months; hearing loss is more frequent but not statistically significant. These outcomes are driven by ZIKV exposure itself, independent of maternal infection characteristics. Our findings highlight the limitations of maternal biomarkers in risk prediction and support incorporating infant-focused developmental outcomes in studies of maternal interventions.

Indexed as

Pregnancy Complications, InfectiousPrenatal Exposure Delayed EffectsZika VirusZika Virus InfectionAnimalsDisease Models, AnimalEmotionsEvoked Potentials, VisualFemaleHumansMacaca mulattaMaleNeurodevelopmentPregnancy

Identifiers

PMID41605918
PMCPMC12917130

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.