Evidence map›Paper›PMID 41605917›Full record

ArticleClinical endoscopy2026

Endoscopic findings are associated with histologic types of primary small intestinal lymphoma: a retrospective study in Japan.

Masafumi Kitamura, Mio Sakaguchi, Hirotsugu Sakamoto, Satoshi Shinozaki, Manabu Nagayama, Tomonori Yano, Yusuke Ono, Takuma Kobayashi, Kunihiko Oguro, Shoko Miyahara and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Masafumi KitamuraDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Mio SakaguchiDepartment of Diagnostic Pathology, Jichi Medical University, Shimotsuke, Japan.
Hirotsugu SakamotoDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Satoshi ShinozakiDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Manabu NagayamaDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Tomonori YanoDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Yusuke OnoDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Takuma KobayashiDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Kunihiko OguroDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Shoko MiyaharaDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Masahiro OkadaDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Katsuyuki NakazawaDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Keijiro SunadaDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Noriyoshi FukushimaDepartment of Diagnostic Pathology, Jichi Medical University, Shimotsuke, Japan.
Hironori YamamotoDepartment of Endoscopic Research and International Education Funded by Fujifilm Medical Co., Ltd., Jichi Medical University, Shimotsuke, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough endoscopic diagnosis of primary small intestinal lymphoma (PSIL) is important, the association between endoscopic findings and histologic types remains unclear. This study aimed to evaluate the diagnostic accuracy of endoscopic classifications and biopsies in PSIL.

methodsWe retrospectively reviewed 100 lesions from 49 patients with PSIL who underwent double-balloon enteroscopy between 2005 and 2020. Endoscopic findings were classified into six macroscopic types: polypoid, ulcerative, multiple nodules, diffuse, concentric stenosis, or unclassified.

resultsOf the 100 lesions, 47 were multiple nodules, 32 were ulcerative, 8 were polypoid, 7 were diffuse, 4 were concentric stenosis, and 2 were unclassified. Diffuse large B-cell lymphoma (DLBCL) was mainly ulcerative (72%) or polypoid (75%), whereas follicular lymphoma appeared as multiple nodules (98%) or concentric stenosis (100%) (p<0.001, Cramér's V=0.41). The ulcerative type was associated with DLBCL (sensitivity, 0.74; specificity, 0.87), and multiple-nodule type were associated with follicular lymphoma (sensitivity, 0.75; specificity, 0.97). The overall diagnostic yield of the biopsy was 95%. Interobserver agreement was substantial (κ=0.69; agreement, 78%).

conclusionsEndoscopic findings were significantly associated with histologic types. Endoscopic findings and biopsies provide a high diagnostic yield, supporting their central role in the diagnostic management of PSIL.

Indexed as

BiopsyEndoscopyHistologic typeLymphomaSmall intestine

Identifiers

PMID41605917
PMCPMC13054490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.