Evidence map›Paper›PMID 41605916›Full record

ArticleClinical endoscopy2026

Touch imprint cytology for rapid on-site evaluation in endoscopic ultrasound-guided tissue acquisition of pancreatic tumors: diagnostic performance and practical value-a single-center retrospective observational study from Japan.

Motoyasu Kan, Sodai Uchida, Taiga Sudo, Kouki Yokozuka, Yoshiki Nakaya, Akinori Abe, Hiroki Kurosaki, Yoshiki Ogane, Kazuki Watabe, Miho Sakai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Motoyasu KanDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sodai UchidaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Taiga SudoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kouki YokozukaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yoshiki NakayaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Akinori AbeDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Hiroki KurosakiDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yoshiki OganeDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Kazuki WatabeDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Miho SakaiDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yu SekineDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Mayu OuchiDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Masayuki YokoyamaBiostatistics Division, Center for Research Administration and Support, National Cancer Center, Tokyo, Japan.
Hiroshi OhyamaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Jun KatoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong various specimen preparation techniques for rapid on-site evaluation (ROSE), touch imprint cytology (TIC) is widely used; however, its utility for pancreatic lesions has not been fully validated. This study aimed to evaluate the diagnostic performance of TIC-based ROSE during endoscopic ultrasound-guided tissue acquisition (EUS-TA) for pancreatic lesions.

methodsThis retrospective study included 385 patients who underwent EUS-TA for pancreatic lesions at a single center. ROSE using TIC was performed in 370 cases (96.1%). Diagnostic concordance between TIC-based ROSE and histology, as well as diagnostic accuracy relative to the final diagnosis, were assessed. The diagnostic performance of TIC was compared with that of spray cytology (SC) and instrument rinse cytology (IRC). Multivariate analysis was conducted to identify factors associated with discordance between TIC-based ROSE and histology.

resultsThe concordance rate between TIC-based ROSE and histology was 85.1% (κ=0.575). For the final diagnosis, TIC-based ROSE demonstrated a sensitivity of 92.3%, specificity of 96.9%, and accuracy of 92.7%, showing superior diagnostic performance within the same workflow compared with SC and IRC. Smaller lesion size and the use of a 25-gauge needle were identified as independent factors for discordance.

conclusionsTIC is a reliable ROSE technique in EUS-TA for pancreatic lesions, providing high diagnostic accuracy and a low inadequacy rate.

Indexed as

CytodiagnosisEndoscopic ultrasonographyFine-needle aspirationPancreatic neoplasmsRapid on-site evaluation

Identifiers

PMID41605916
PMCPMC13439285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.