Evidence map›Paper›PMID 41605845›Full record

ArticleThe Journal of comparative neurology2026

Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment.

Anna Lysakowski, Aravind Chenrayan Govindaraju, Steven D Price, Sophie Gaboyard-Niay, Irina Calin-Jageman, Robstein L Chidavaenzi, Ruth Anne Eatock, Robert M Raphael, Jay M Goldberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Autism associatedbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna LysakowskiDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, USA.
Aravind Chenrayan GovindarajuDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Steven D PriceDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, USA.
Sophie Gaboyard-NiayDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, Illinois, USA.
Irina Calin-JagemanDepartment of Biological Sciences, Dominican University, River Forest, Illinois, USA.
Robstein L ChidavaenziDepartment of Biomedical Foundations, Ross University, School of Medicine, Bridgetown, St. Michael, Barbados.
Ruth Anne EatockDepartment of Neurobiology, University of Chicago, Chicago, Illinois, USA.
Robert M RaphaelDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Jay M GoldbergDepartment of Pharmacological and Physiological Sciences, University of Chicago, Chicago, Illinois, USA.

Funding

CELLULAR MECHANISMS OF THE VESTIBULAR SYSTEMR01DC002058 · NIDCD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GOLDBERG, JAY M, LYSAKOWSKI, ANNA · 1993 to 2014
$5.3M
Synaptic Processing in the Vestibular SystemR01DC012347 · NIDCD · UNIVERSITY OF CHICAGO · PI EATOCK, RUTH ANNE, LYSAKOWSKI, ANNA · 2012 to 2022
$5.2M
Cellular Mechanisms of the Vestibular SystemR56DC002058 · NIDCD · UNIVERSITY OF CHICAGO · PI GOLDBERG, JAY M, LYSAKOWSKI, ANNA · 2009 to 2009
$471k
How Peripheral Vestibular Signals Create Vestibular Compound Action PotentialsR21DC022412 · NIDCD · RICE UNIVERSITY · PI Aravind Chenrayan Govindaraju · 2025 to 2026
$391k
NIDCD NIH HHS R01 DC002058NIDCD NIH HHS R01 DC012347NIDCD NIH HHS R21 DC022412NIDCD NIH HHS R56 DC002058NIH HHS
6 · The paper itself

Abstract

The amniote inner ear contains an unusual type of hair cell and a unique postsynaptic calyx terminal with specialized ion channel expression and afferent transmission mechanisms. The calyceal afferent terminal enwraps the hair cell and leads to a heminode. It has morphological and functional microdomains with distinct complements of potassium channels and scaffolding proteins. Stimulation of hair cells gives rise to postsynaptic potentials in the membrane facing the hair cell that propagate along the outer face of the calyx and parent axon to the heminode, giving rise to spikes with timing and response properties that vary with location (epithelial zone) and afferent morphology (calyx-only vs. dimorphic with additional bouton terminals). Heminodes of calyx-only afferents lie within the epithelium, placing the calyces themselves closer to the heminode. We report that diverse voltage-gated sodium (Na

Indexed as

Axon Initial SegmentAxonsHair Cells, VestibularVestibule, LabyrinthVoltage-Gated Sodium ChannelsAnimalsAnkyrinsFemaleMiceSpectrinAnk3 protein, mouseAnkyrinsSpectrinVoltage-Gated Sodium ChannelsankyrinCasprHCNinner earNa channelsRRID:AB_10120130RRID:AB_10673030RRID:AB_10673094RRID:AB_10673095RRID:AB_10673154RRID:AB_10673165RRID:AB_10675130RRID:AB_177503RRID:AB_2040007RRID:AB_2040009RRID:AB_2040200RRID:AB_2040202RRID:AB_2040204RRID:AB_2068506RRID:AB_2083496RRID:AB_2115181RRID:AB_2183861RRID:AB_2184030RRID:AB_2184197RRID:AB_2184355RRID:AB_2238842RRID:AB_2245198RRID:AB_2256033RRID:AB_2271840RRID:AB_2279449RRID:AB_2296313RRID:AB_2301402RRID:AB_2341071RRID:AB_261544RRID:AB_477552RRID:AB_87580RRID:AB_90764RRID:AB_94259

Identifiers

PMID41605845
PMCPMC12852067

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.