Evidence map›Paper›PMID 41605843›Full record

SynthesisInternational wound journal2026

Effects of Near Infrared Light on Surgical Wound Healing: A Systematic Review and Meta-Analysis.

Junyan Liu, Varun Gopal, Brian Ellis, Ian Ray, Suguna Pappu, Yih-Kuen Jan

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International wound journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junyan LiuDepartment of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Varun GopalCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Brian EllisCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Ian RayCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Suguna PappuCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Yih-Kuen JanDepartment of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID https://orcid.org/0000-0001-7149-4034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near infrared (NIR) therapy is increasingly used to enhance postoperative wound healing, yet clinical trial results remain inconsistent. To evaluate the effectiveness of NIR therapy on postoperative wound healing and identify treatment parameters associated with optimal outcomes: This systematic review and meta-analysis registered at PROSPERO (CRD420251163415) assessed evidence on comparing NIR therapy (630-1100 nm) with standard care or placebo on healing of surgical-induced wounds. A multilevel random-effects meta-analysis of standardised mean differences (SMDs) was conducted. Moderator analyses examined the wavelength, fluence, session number, application technique and anatomical site. Risk of bias was assessed using Cochrane RoB 2.0 and certainty of evidence was rated with GRADE. Fifty-six trials (N = 4920) were included for systematic review and 35 trials contributed 69 outcomes to meta-analysis. NIR significantly improved wound healing (0.78, [0.46-1.09], p < 0.01) and reduced postoperative pain (0.71, [0.24-1.17], p < 0.01), but heterogeneity was high and effects varied across studies. Optimal outcomes were associated with short NIR wavelengths (700-850 nm), 4-10 sessions and non-contact application. Effects on swelling, scarring and inflammatory markers were inconsistent. Overall, certainty of evidence was very low. This first systematic review and meta-analysis indicates that NIR therapy demonstrates promise for enhancing postoperative healing and reducing pain, though effects vary by protocols.

Indexed as

Infrared RaysSurgical WoundWound HealingHumansTreatment Outcomelow‐level laser therapynear‐infrared lightphotobiomodulationsurgical recoverytissue regeneration

Identifiers

PMID41605843
PMCPMC12851903

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.