Evidence map›Paper›PMID 41605799›Full record

ArticleJournal of microbiology and biotechnology2026

Integrated Microbiome and Metabolomic Profiling to Identify Potential Biomarkers of Major Depressive Disorder.

Hyunjung Lee, Mee-Hyun Lee, Seung-Ho Seo, Juhan Pak, Soobin Bae, Gayoun Lee, Hyun Sik Kim, Kyeongok Kim, Jae-Hong Kim, Hong-Seok Son

Abstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyunjung LeeDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Mee-Hyun LeeCollege of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
Seung-Ho SeoCollege of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
Juhan PakDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Soobin BaeDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Gayoun LeeDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Hyun Sik KimDepartment of Biology, College of Science, Kyung Hee University, Seoul 02447, Republic of Korea.
Kyeongok KimDepartment of Neuropsychiatry, College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
Jae-Hong KimDepartment of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
Hong-Seok SonDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathophysiology of major depressive disorder (MDD) remains incompletely understood, hindering the development of objective diagnostic markers. While the microbiota-gut-brain axis is implicated in MDD, the functional link between gut dysbiosis and systemic metabolism remains largely obscure. To address this, we employed an integrated multi-omics approach combining 16S rRNA gene sequencing, GC-MS analysis of urine and plasma, complemented by UPLC-QTOF-MS profiling of plasma, in a Korean cohort (

Indexed as

BiomarkersGastrointestinal MicrobiomeMajor Depressive DisorderMetabolomeMetabolomicsAdultBacteriaCarnitineDysbiosisFatty AcidsFemaleGas Chromatography-Mass SpectrometryHumansMaleMiddle AgedMultiomicsacylcarnitineBiomarkersCarnitineFatty AcidsRNA, Ribosomal, 16SGut-brain axisGut microbiotaMajor depressive disorderMetabolomicsMulti-omics

Identifiers

PMID41605799
PMCPMC12868950

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.