ArticleInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society2026
Opportunistic salpingectomy during gynecologic and non-gynecologic abdominopelvic procedures for ovarian cancer primary prevention: a cost-effectiveness analysis.
Article in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Ovarian cancer risk reduction by salpingectomy during non-gynaecological surgery: scoping review.BJS open · 2024Article
- Assessment of Perceptions and Practices in Primary Care Providers Regarding Opportunistic Salpingectomy.Journal of primary care & community healthArticle
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Abstract
objectiveOpportunistic salpingectomy during gynecologic surgeries is associated with a 49% to 77% reduction in ovarian cancer. The impact of the adoption of opportunistic salpingectomy during non-gynecologic abdominopelvic procedures on ovarian cancer-related outcomes is not well-established. We performed cost-effectiveness analyses to assess the impact of opportunistic salpingectomy during 6 common abdominopelvic procedures.
methodsThe cost-effectiveness of opportunistic salpingectomy during laparoscopic hysterectomy, appendectomy, cholecystectomy, gastric bypass, abdominal hernia repair, and colectomy was estimated from the United States single-payer perspective. Markov models were constructed using TreeAge Pro Healthcare software (Version 2023-R1.2) to assess the incremental costs, quality-adjusted life-years, and net monetary benefit associated with opportunistic salpingectomy for each procedure performed for a hypothetical cohort of average-risk United States patients aged 40 years based on the real-world incidence of these procedures within the Merative MarketScan Database. Model inputs were extracted from published literature. Univariate and probabilistic sensitivity analyses were performed.
resultsA total of 8633 procedures were identified in MarketScan in 2019 for the hypothetical cohort of 40-year-old patients. Opportunistic salpingectomy during the 6 procedures was incrementally cost-saving ($2176) with more quality-adjusted life-years gained (5.18) from a lifetime perspective, with a net monetary benefit of $520,773. Opportunistic salpingectomy at the time of the 6 procedures for the hypothetical cohort yielded $18.78 million in health care dollars saved, which was derived by multiplying the total number of procedures (8633) by the per-procedure weighted average savings ($2176). Probabilistic sensitivity analyses found that for each procedure, performing opportunistic salpingectomy had less cost and more quality-adjusted life-years gained in over 99% of the 10,000 Monte Carlo simulations.
conclusionsWidespread adoption of opportunistic salpingectomy during these common abdominopelvic procedures is robustly cost-saving. With no effective general population screening and the high cost and mortality associated with ovarian cancer, performing opportunistic salpingectomy with any of the 6 procedures may be merited.
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