Evidence map›Paper›PMID 41605541›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2026

Host- and pathogen-related determinants of pulmonary

Begna Tulu, Thomas Theo Brehm, Reinout van Crevel, Tobias Dallenga, Andrew R DiNardo, Keertan Dheda, Johanna Eggeling, Wendemagegn Enbiale, Matthias I Gröschel, Jialun Hao and 13 more

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Genome-wide transcriptional landscape ofFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Begna TuluDivision of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.ORCID 0000-0003-1341-9559
Thomas Theo BrehmDivision of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Reinout van CrevelDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Tobias DallengaGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
Andrew R DiNardoDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Keertan DhedaDivision of Pulmonology and UCT Lung Institute, Department of Medicine, Centre for Lung Infection and Immunity, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Johanna EggelingDivision of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.ORCID 0009-0002-9831-9185
Wendemagegn EnbialeDepartment of Dermatovenereology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Matthias I GröschelGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
Jialun HaoDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Vinod KumarDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Arjan van LaarhovenDepartment of Internal Medicine, Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.
Rolanda LondtDivision of Pulmonology and UCT Lung Institute, Department of Medicine, Centre for Lung Infection and Immunity, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Gareth ProsserGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
Philippa RandallDivision of Pulmonology and UCT Lung Institute, Department of Medicine, Centre for Lung Infection and Immunity, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Norbert ReilingGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
Jan RybnikerDivision of Infectious Diseases, Department of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Ulrich E SchaibleGerman Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
Erwin SchurrProgram in Infectious Diseases and Immunity in Global Health, Research Institute, McGill University Health Centre, Montreal, QC, Canada.
Isabelle SuarezDivision of Infectious Diseases, Department of Internal Medicine, University Hospital Cologne, Cologne, Germany.ORCID 0000-0002-9863-9675
Sebastian J TheobaldDivision of Infectious Diseases, Department of Internal Medicine, University Hospital Cologne, Cologne, Germany.
Robert J WilkinsonWellcome Discovery Research Platforms in Infection, Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine and Department of Medicine, University of Cape Town, Cape Town, South Africa.
Christoph LangeDivision of Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany clange@fz-borstel.de.ORCID 0000-0002-9691-4741

Funding

Wellcome Trust
6 · The paper itself

Abstract

Tuberculosis (TB) primarily manifests as pulmonary TB (PTB), but extrapulmonary TB (EPTB) remains a major clinical challenge. Distinct diagnostic and therapeutic difficulties arise from differences in immune responses, pathogen behaviour and host susceptibility. However, the factors driving disease localisation are still incompletely understood. We conducted a comprehensive narrative review of studies examining differences between PTB and EPTB in terms of epidemiology, mycobacterial factors, genetic and epigenetic determinants, host immune responses, transcriptomic profiles, cytokine and chemokine patterns, and immunophenotypes. EPTB is more common among females, children, older adults and immunocompromised individuals with deficient granuloma formation. This review is intended to provide deeper insight for clinicians and researchers and provides an accessible synthesis of current basic science findings together with their relevance for clinical practice. Certain

Indexed as

LungMycobacterium tuberculosisTuberculosis, ExtrapulmonaryTuberculosis, PulmonaryAnimalsCytokinesEpigenesis, GeneticGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansPhenotypePrognosisRisk FactorsCytokines

Identifiers

PMID41605541
PMCPMC12873656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.