Evidence map›Paper›PMID 41605285›Full record

ArticleJournal of advanced research2026

OSBPL6 protects against demyelination and behavioral disorder via promoting cholesterol transport in oligodendrocyte.

Mengni Chang, Kaiqi Zhang, Ye Li, Xiao Chen, Tian Lan, Yan Zhu, Wenjing Wang, Changmin Wang, Xianghua Zhuang, Shihong Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengni ChangThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Kaiqi ZhangThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Ye LiThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Xiao ChenThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Tian LanThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Yan ZhuThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Wenjing WangThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Changmin WangThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China.
Xianghua ZhuangDepartment of Endocrinology and Metabolism, The Second Hospital of Shandong University, Jinan, Shandong Province 250033, China. Electronic address: zhuangxianghua@email.sdu.edu.cn.
Shihong ChenDepartment of Endocrinology and Metabolism, The Second Hospital of Shandong University, Jinan, Shandong Province 250033, China. Electronic address: chenshihong@sdu.edu.cn.
Shuyan YuThe Second Hospital of Shandong University, Jinan, Shandong Province 250012, China; Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250012, China; Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Shandong University, Jinan, Shandong Province 250012, China. Electronic address: shuyanyu@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDemyelination is associated with behavioral disorder and cognitive impairment in neuropsychiatric diseases, including major depressive disorder (MDD). However, the mechanism underlying myelin damage remains unclear, despite stress maybe a major risk factor.

objectivesHere, we demonstrate that hippocampal neurons in the chronic stress-induced depressive mice are prone to demyelination due to disrupted cholesterol transport to myelin sheaths in oligodendrocyte. METHODS AND

resultsSingle-nucleus RNA sequencing of lipid metabolism-related signaling pathway revealed significant reduced levels of oxysterol binding protein-like 6 (OSBPL6) in hippocampal oligodendrocytes of depression mouse model. Consistently, specific knockdown of OSBPL6 in oligodendrocytes induced loss of myelin structure, while upregulating OSBPL6 or enhancing OSBPL6 transcription improved these impairments in depressive mice. Furthermore, restoring cholesterol transport with β-cyclodextrin decreased cholesterol accumulation, improved damaged myelin structure, and rescued depression-related behaviors in depressive mice.

conclusionsThese findings suggest that OSBPL6-mediated cholesterol homeostasis in oligodendrocytes can promote myelin production against chronic stress-induced cerebral demyelination and depression with behavioral disorders.

Indexed as

CholesterolDemyelinating DiseasesOligodendrogliaReceptors, SteroidAnimalsBiological TransportDepressionDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLMyelin SheathOxysterol Binding ProteinsCholesterolOxysterol Binding ProteinsReceptors, SteroidCholesterol homeostasisDemyelinationDepressionOligodendrocyteOSBPL6

Identifiers

PMID41605285
PMCPMC13669676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.