ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2026
The sublingual vaccine MV140 is dominant over prophylactic antibiotics for the prevention of recurrent, uncomplicated urinary tract infections in adult women A cost-utility analysis.
Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecurrent, uncomplicated urinary tract infections (rUTIs) in women are associated with burdensome symptoms, high antibiotic use, and significant costs. The sublingual vaccine MV140 has demonstrated significant reduction in rUTI rates in Canada and Europe. This analysis examined the cost-effectiveness of MV140 as an alternative to prophylactic antibiotics (pAbs) for rUTI prevention in adult women in the Canadian healthcare setting.
methodsA cost-utility model was developed to follow rUTI patients over 1.25 years through four health states: UTI-free survival, acute UTI, pyelonephritis, and death. A decision tree was used to model the acute UTI state, accounting for Ab resistance and choice of first-line Ab treatment, while Markov model transition probabilities were derived from a published direct comparison. Cost inputs included drug acquisition/administration, healthcare resource use, adverse events, and lost productivity, and were based on Canadian governmental resources. Utilities were derived from published literature. The base case was probabilistic (n=5000); multiple one-way sensitivity analyses were performed to assess model uncertainty.
resultsMV140 was associated with cost-savings (-$1442) and increased quality of life years (0.01) compared to pAbs, with an incremental cost-effectiveness ratio of -$229 088 in the base case (societal perspective). MV140 remained dominant over pAbs in most scenario analyses, with incremental costs ranging from -$256 207 to $875.
conclusionsMV140 represents a consistently cost-effective alternative to pAbs in the Canadian healthcare system. When societal costs are considered, MV140 is consistently dominant over pAbs irrespective of variation in scenario inputs, demonstrating the considerable economic value of MV140 in this disease setting.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.