Evidence map›Paper›PMID 41604667›Full record

ArticleJournal of medical Internet research2026

The Development and Use of AI Chatbots for Health Behavior Change: Scoping Review.

Lingyi Fu, Ryan Burns, Yuhuan Xie, Jincheng Shen, Shandian Zhe, Paul Estabrooks, Yang Bai

Registry-linked trialAbstract readScoping Review
In one paragraph

Article in Journal of medical Internet research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07612800 (Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07612800 nanot yet recruitingnot on this map

Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention (THINK-SHARP)

TypeinterventionalSponsorAlexandra HospitalRan2026 to 2029Enrolled350ConditionsMCI, DementiaArmsBLAZE (Brain health Lifestyle Action with personaliZed Engagement)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingyi FuDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-2256-6414
Ryan BurnsDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-5933-4633
Yuhuan XieDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0009-0006-6404-5461
Jincheng ShenDepartment of Internal Medicine, School of Medicine, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-6551-3558
Shandian ZheKahlert School of Computing, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0003-0316-9875
Paul EstabrooksDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0003-2261-9886
Yang BaiDepartment of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0001-6751-3896

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArtificial intelligence (AI) chatbots are technologies that facilitate human-computer interaction through communication in a natural language format. By increasing cost-effectiveness, interaction, autonomy, personalization, and support, mobile health interventions can benefit health behavior change and make it more natural and intuitive.

objectiveThis study aimed to provide an up-to-date and practical overview of how text-based AI chatbots are designed, developed, and evaluated across 8 health behaviors, including their roles, theoretical foundations, health behavior change techniques, technology development workflow, and performance validation framework.

methodsIn accordance with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) framework, relevant studies published before March 2024 were identified from 9 bibliographic databases (ie, PubMed, CINAHL, MEDLINE, Embase, Web of Science, Scopus, APA PsycINFO, IEEE Xplore, and ACM Digital Library). Two stages (ie, title and abstract screening followed by full-text screening) were conducted to screen the eligibility of the papers via Covidence software. Finally, we extracted the data via Microsoft Excel software and used a narrative approach, content analysis, and evidence map to synthesize the reported results.

resultsOur systematic search initially identified 10,508 publications, 43 of which met our inclusion criteria. AI chatbots primarily served 2 main roles: routine coach (27/43, 62.79%) and on-demand assistant (12/43, 27.91%), while 4 studies (4/43, 9.30%) integrated both roles. Frameworks like cognitive behavioral therapy (13/24, 54.17%) and behavior change techniques, such as goal setting, feedback and monitoring, and social support, guided the development of theory-driven AI chatbots. Noncode platforms (eg, Google Dialogflow and IBM Watson) integrated with social messaging platforms (eg, Facebook Messenger) were commonly used to develop AI chatbots (23/43, 53.49%). AI chatbots have been evaluated across 4 domains: technical performance (17/43, 39.53%), usability (17/43, 39.53%), engagement (37/43, 86.05%), and health behavior change (33/43, 76.74%). Evidence for health behavior changes remains exploratory but promising. Among 33 studies with 120 comparisons, 81.67% (98/120) showed positive outcomes, though only 35.83% (43/120) had moderate or larger effects (Hedges g or odds ratio or Cohen d>0.5). Most involved nonclinical (36/43, 83.72%) and adults (23/43, 53.49%), and a few were randomized controlled trials (14/43, 32.56%). Benefits were mainly seen in physical activity, smoking cessation, stress management, and diet, with limited evidence for other behaviors. Findings were inconsistent regarding the influence of long-term effects, intervention duration, modality, and engagement on health behavior change outcomes.

conclusionsThe exploratory synthesis provides a roadmap for developing and evaluating AI chatbots in health behavior change, highlighting the need for further research on cost, implementation outcomes, and underexplored behaviors such as sleep, weight management, sedentary behavior, and alcohol use.

Indexed as

Generative Artificial IntelligenceHealth BehaviorHumansTelemedicineconversational agentdiethealth behavior changemachine learningphysical activitysleep

Identifiers

PMID41604667
PMCPMC12895150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.