Article in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Emily R Siniscalco *Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5065-1854
Courtney Fisher *Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-9206-9926
Meng-Ping Lu *Department of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-3056-3026
Jessica D S GrassmannThe Jackson Laboratory for Genomic Medicine , Farmington, CT, USA.ORCID 0000-0001-9076-452X
Corinne D MackHuman Immune Disorders Laboratory, Garvan Institute of Medical Research , Sydney, Australia.ORCID 0000-0002-0887-5915
Roukaya YaakoubiDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0009-0002-3784-0137
Danielle JacobsenDivision of Allergy and Immunology, The Department Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-2288-3858
Qian ChenDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-7771-2802
Donguk LeeDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-9431-0303
Priya RajamanimuthuDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0004-5922-4882
Tregony SimoneauDivision of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2407-4402
Paul GrayDepartment of Immunology and Infectious Diseases, Sydney Children's Hospital, Sydney, Australia.ORCID 0000-0003-2057-3968
Satoshi OkadaDepartment of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0002-4622-5657
Bertrand BoissonSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.ORCID 0000-0001-5240-3555
Basak KayaogluLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0002-5752-3086
Jeffrey DanielsonLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0003-1916-3806
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0001-7005-8345
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University , New York, NY, USA.ORCID 0000-0002-7782-4169
Talal A ChatilaDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-7439-2762
Helen C SuLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.ORCID 0000-0002-5582-9110
Cindy S MaHuman Immune Disorders Laboratory, Garvan Institute of Medical Research , Sydney, Australia.ORCID 0000-0001-5387-8413
Adam WilliamsThe Jackson Laboratory for Genomic Medicine , Farmington, CT, USA.ORCID 0000-0002-5151-4103
Stephanie C EisenbarthDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1244-208X
Uthaman GowthamanDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-5484-7851
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CASANOVA, JEAN-LAURENT · 2004 to 2021
$29.8M
Immune Mechanisms Regulating AllergyR01AI136942 · NIAID · YALE UNIVERSITY · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2018 to 2026
$5.1M
Determinants of oral anaphylaxis to foodR01AI168016 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2023 to 2026
$3.2M
Mechanisms of Combined Immunodeficiency due to DOCK8 DeficiencyR01AI128976 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE · 2018 to 2021
$1.4M
Generation & Regulation of Tfh13 cells that drive Pathogenic IgE in AllergyR01AI187460 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOWTHAMAN UTHAMAN · 2025 to 2026
$1.2M
Allergy and Immunology Foundation of AustralasiaCharles Hood FoundationFondation du SouffleFood Allergy Science InitiativeFrench Foundation for Medical Research EQU202503020018French National Research Agency ANR-10-IAHU-01Grandir-Fonds de Solidarité Pour l'EnfanceHoward Hughes Medical InstituteImagine InstituteInstitut National de la Santé et de la Recherche MédicaleIntegrative Biology of Emerging Infectious Diseases Laboratory of Excellence ANR-10-LABX-62-IBEIDNational Health and Medical Research Council of Australia 2017463National Institute of Allergy and Infectious Diseases R01AI128976, R01 AI187460, R01 AI136942, R01 AI168016NCATS NIH HHS UL1 TR001866NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI128976NIAID NIH HHS R01 AI136942NIAID NIH HHS R01 AI168016NIAID NIH HHS R01 AI187460NIH HHS P01AI061093NIH HHS UL1TR001866Paris Cité UniversitySmith Family FoundationSquare FoundationSt. Giles FoundationThe Rockefeller University
6 · The paper itself
Abstract
Patients with loss-of-function DOCK8 or dominant-negative STAT3 variants have hyper-IgE syndrome, although only DOCK8 deficiency consistently presents with elevated food-specific IgE and symptomatic allergy. We previously found in mice that DOCK8 restricts the differentiation of IL-13+ T follicular helper (Tfh13) cells that drive anaphylactic IgE, although the mechanisms were unclear. Here, we show that DOCK8 promotes STAT3 activity, which inhibits GATA3 in T cells. However, only patients with DOCK8, but not STAT3, deficiency had elevated Tfh13 cells. Cell-specific deletion of either Dock8 (T-Dock8-/-) or Stat3 (T-Stat3-/-) augmented peanut-specific IgE and Tfh13s when oral sensitization was promoted by adjuvants. However, the phenotypes diverged during adjuvant-free oral peanut exposure: only T-Dock8-/- mice developed Tfh13 cells and peanut-specific IgE, accompanied by reduced Foxp3+ Tregs. Treg depletion in T-Stat3-/- mice unmasked Tfh13 induction to oral antigen alone. Thus, DOCK8 and STAT3 cooperate to restrain Tfh13 differentiation to food allergens, and additional Treg impairment in DOCK8 deficiency allows for Tfh13 cell induction and allergy.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. · full record | OpenQuestion