Reply to "Comment on 'De Novo Reconstruction of 3D Human Facial Images From DNA Sequence'".

Mingqi Jiao, Jiarui Li, Chunman Zuo, Sijia Wang, Luonan Chen

Abstract readCommentLetter

In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mingqi JiaoKey Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Hangzhou, China.ORCID 0009-0007-4996-2402

Jiarui LiCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Chunman ZuoSchool of Life Sciences, SunYat-sen University, Guangzhou, China.

Sijia WangCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Luonan ChenKey Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Hangzhou, China.ORCID 0000-0002-3960-0068

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This manuscript is a formal response to the Comment by Wagner et al. regarding our publication "De Novo Reconstruction of 3D Human Facial Images from DNA Sequence." We clarify the methodological rationale, analytical procedures, and scientific scope of our original study, and we address several misconceptions arising in the Comment. We further highlight the intended purpose and limitations of Difface and discuss ongoing efforts to advance the rigor, interpretability, and ethical governance of DNA-based 3D facial prediction.

Indexed as

DNAFaceImage Processing, Computer-AssistedImaging, Three-DimensionalSequence Analysis, DNAHumansDNA

Identifiers

PMID41604506

DOI10.1002/advs.73979

PMCPMC13042351

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.