Evidence map›Paper›PMID 41604481›Full record

ArticleScience advances2026

Efflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteria.

Subrata Dev, Keiran Stevenson, Dai Le, Minsu Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Subrata DevDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-3629-8032
Keiran StevensonDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-0622-063X
Dai LeDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-6395-6163
Minsu KimDepartment of Physics, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-1594-4971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial efflux pumps are major contributors to multidrug resistance, classically described as "gatekeepers" that reduce drug entry. Here, we uncover a post-entry mechanism of efflux pumps, revealing their function deep into intracellular drug-target interactions. Using quantitative live-cell imaging, we monitored the activity of major efflux systems in

Indexed as

Anti-Bacterial AgentsBacterial ProteinsEscherichia coliMembrane Transport ProteinsPseudomonas aeruginosaBenzimidazolesDrug Resistance, Multiple, BacterialEscherichia coli ProteinsKineticsProtein BindingAnti-Bacterial AgentsBacterial ProteinsBenzimidazolesbisbenzimide ethoxide trihydrochlorideEscherichia coli ProteinsMembrane Transport Proteins

Identifiers

PMID41604481
PMCPMC13150710

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.