Evidence map›Paper›PMID 41604475›Full record

ArticleScience advances2026

CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation.

Jae Yeon Hwang, Huafeng Wang, Jong-Nam Oh, Jingon Kim, Sarah F Finnegan, Niels E Skakkebaek, Jean-Ju Chung

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jae Yeon HwangDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6493-4182
Huafeng WangDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7326-4379
Jong-Nam OhDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9026-3725
Jingon KimDepartment of Integrated Biological Science, Pusan National University, Busan, South Korea.
Sarah F FinneganDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0000-5808-3214
Niels E SkakkebaekDepartment of Growth & Reproduction and EDMaRC, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4282-8020
Jean-Ju ChungDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8018-1355

Funding

CatSper regulation of sperm physiology and fertilityR01HD096745 · NICHD · YALE UNIVERSITY · PI Jean-Ju Lucia Chung · 2019 to 2026
$3.4M
NICHD NIH HHS R01 HD096745
6 · The paper itself

Abstract

The sperm flagellar-specific CatSper Ca

Indexed as

Calcium ChannelsSpermatozoaAnimalsCalciumMaleMiceProtein DomainsSpermatogenesisSperm CapacitationSperm ProteinsCalciumCalcium ChannelsCatsper1 protein, mouseSperm Proteins

Identifiers

PMID41604475
PMCPMC12851028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.