Evidence map›Paper›PMID 41604474›Full record

ArticleScience advances2026

Single-particle surface-enhanced coherent anti-Stokes Raman scattering: Nanoparticle design and mechanism.

Sanjun Fan, Ran Cheng, Haonan Lin, Zhewen Luo, Abigail E Smith, Chih-Feng Wang, Jinna He, Brian T Scarpitti, Deben N Shoup, Hannah C Schorr and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sanjun FanDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-8192-9580
Ran ChengDepartment of Chemistry, Boston University, Boston, MA 02215, USA.
Haonan LinDepartment of Electrical and Computer Engineering and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-0437-5902
Zhewen LuoSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
Abigail E SmithDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Chih-Feng WangPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.ORCID 0000-0002-3085-6614
Jinna HeSchool of Electric and Mechanical Engineering, Pingdingshan University, Pingdingshan 467000, China.ORCID 0000-0002-6771-8231
Brian T ScarpittiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-5819-9866
Deben N ShoupDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Hannah C SchorrDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0000-1836-6893
Erjun LiangSchool of Physics and Laboratory of Zhongyuan Light, Zhengzhou University, Zhengzhou 450001, China.ORCID 0000-0001-8601-3221
Jian YeSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0000-0002-8101-8362
Ji-Xin ChengDepartment of Electrical and Computer Engineering and Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-5607-6683
Zachary D SchultzDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-1741-8801

Funding

Targeted TERS Investigations of Ligand-Receptor BindingR01GM109988 · NIGMS · UNIVERSITY OF NOTRE DAME · PI SCHULTZ, ZACHARY · 2015 to 2024
$3.2M
NIGMS NIH HHS R01 GM109988
6 · The paper itself

Abstract

Surface-enhanced coherent anti-Stokes Raman scattering (SECARS) is believed to increase the signal intensity and sensitivity by combining the localized surface plasmon resonance and coherent Raman enhancement. However, the realization of SECARS is more complex than for surface-enhanced Raman scattering (SERS) and remains challenging. Unlike SERS, the nonlinear CARS process requires the coherent interaction of three distinct fields. The interactions between the electric fields and nanoparticle (NP) morphology for single-particle SECARS remain unexplored, and the underlying mechanisms generating the SECARS signal are not fully understood. Here, 27 distinct NPs were synthesized and screened using a CARS microscope. Among them, only star-core core-satellite NPs show single-particle SECARS signals, which were affected by laser polarization, two-photon luminescence background, photoinduced heating effects, particle size, and particle morphology. The influence of NP properties on SECARS enhancement offers guidance for the design and synthesis of NPs for single-particle SECARS and opportunities in biological imaging and chemical sensing.

Identifiers

PMID41604474
PMCPMC12851029

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