Evidence map›Paper›PMID 41604452›Full record

ArticleeLife2026

Allosteric effects of the coupling cation in melibiose transporter MelB.

Parameswaran Hariharan, Yuqi Shi, Amirhossein Bakhtiiari, Ruibin Liang, Rosa Viner, Lan Guan

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structure and allostery in major facilitator superfamily symport mechanisms.Acta crystallographica. Section D, Structural biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Parameswaran HariharanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, United States.ORCID https://orcid.org/0000-0002-6020-1547
Yuqi ShiThermo Fisher Scientific, San Jose, United States.ORCID https://orcid.org/0009-0000-0825-7933
Amirhossein BakhtiiariDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States.ORCID https://orcid.org/0000-0002-3979-0973
Ruibin LiangDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, United States.ORCID https://orcid.org/0000-0001-8741-1520
Rosa VinerThermo Fisher Scientific, San Jose, United States.ORCID https://orcid.org/0000-0003-0550-5545
Lan GuanDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, United States.ORCID https://orcid.org/0000-0002-2274-361X

Funding

Understanding electronically non-adiabatic reactions in biomolecules with multiscale simulationsR35GM150780 · NIGMS · TEXAS TECH UNIVERSITY · PI Ruibin Liang · 2023 to 2026
$1.4M
An integrated approach to understanding the molecular mechanisms of cation-coupled transportR35GM153222 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Lan Guan · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM150780NIGMS NIH HHS R35 GM153222NIH HHS R35 GM150780NIH HHS R35 GM153222
6 · The paper itself

Abstract

The major facilitator superfamily (MFS) transporters play significant roles in human health and disease.

Indexed as

Bacterial ProteinsCationsMelibioseMembrane Transport ProteinsSalmonella typhimuriumSodiumSymportersAllosteric RegulationCrystallography, X-RayHydrogen Deuterium Exchange-Mass SpectrometryMolecular Dynamics SimulationProtein BindingProtein ConformationBacterial ProteinsCationsMelibiosemelibiose permeaseMembrane Transport ProteinsSodiumSymportersallosterycouplingE. coliHDX-MSmobile barriermolecular biophysicsmolecular dynamics simulationsstructural biologystructural dynamicssugar recognitionsymport

Identifiers

PMID41604452
PMCPMC12851581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.