Evidence map›Paper›PMID 41604397›Full record

ArticlePLOS global public health2026

Spreading potential in disease relevant networks: Predicting centralities in rural Northeast Madagascar.

Camille M M DeSisto, Raquel A Binder, Kayla Kauffman, Tyler M Barrett, Michelle Pender, Randall A Kramer, Voahangy Soarimalala, Jean Yves Rabezara, Prisca Rahary, James Moody and 1 more

Abstract read
In one paragraph

Article in PLOS global public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Camille M M DeSistoNicholas School of the Environment, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0002-8828-2334
Raquel A BinderDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.ORCID https://orcid.org/0000-0001-8179-4145
Kayla KauffmanDepartment of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, California, United States of America.ORCID https://orcid.org/0000-0002-4897-9428
Tyler M BarrettDepartment of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.ORCID https://orcid.org/0000-0001-8166-8704
Michelle PenderDuke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
Randall A KramerNicholas School of the Environment, Duke University, Durham, North Carolina, United States of America.
Voahangy SoarimalalaAssociation Vahatra, Antananarivo, Madagascar.
Jean Yves RabezaraAssociation Vahatra, Antananarivo, Madagascar.
Prisca RaharyAssociation Vahatra, Antananarivo, Madagascar.
James MoodyDepartment of Sociology, Duke University, Durham, North Carolina, United States of America.
Charles L NunnDepartment of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.

Funding

University of Massachusetts Center for Clinical and Translational ScienceKL2TR001455 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2015 to 2024
$5.0M
The Impact of Land Use Change on Transmission Potential Networks and Disease Spread in Rural MadagascarR01TW011493 · FIC · DUKE UNIVERSITY · PI NUNN, CHARLES · 2019 to 2023
$2.6M
FIC NIH HHS R01 TW011493NCATS NIH HHS KL2 TR001455
6 · The paper itself

Abstract

Heterogeneity in contact patterns can have marked effects on disease transmission, including through superspreading where few individuals drive most infections. Networks based on different types of human-human contacts quantify individuals' centrality, which can be used to identify individuals or sub-populations who are at increased risk of spreading disease. By understanding the predictors of centrality, high-risk individuals and sub-populations can be targeted to improve public health intervention strategies, even when detailed network data are unavailable. This study inferred transmission potential networks representing different pathogen transmission pathways among people living in rural villages of northeast Madagascar. We constructed four network types: social, close contact, household proximity, and environmental overlap using survey data and global positioning system (GPS) trackers. We then investigated how sociodemographic and anthropometric variables predicted different types of network centralities using multiple mixed effects linear models. Gender and wealth based on household material quality tended to be the most important sociodemographic predictors of centrality, but centrality outcomes varied by network type and had wide confidence intervals. Men tended to be more central to their environmental overlap network than women. Further, wealth based on household materials was an important, positive predictor of close contact network centrality. Gender and wealth were associated with centrality in transmission-potential networks but varied in their importance across different network types. Our study results suggest that targeted intervention efforts focused on diseases that are transmitted through shared environments (i.e., parasites shared through soil or water) or direct contact (i.e., respiratory infections) in similar agricultural settings should consider gender- and wealth-associated differences in contact patterns.

Identifiers

PMID41604397
PMCPMC12851470

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.