SynthesisClinical and translational gastroenterology2026
Machine Perfusion Ameliorates Nonanastomotic Strictures After Liver Transplantation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Synthesis in Clinical and translational gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Machine-perfused Donation After Circulatory Death Grafts Improve Access to Liver Transplant for Primary Biliary Cholangitis Patients.Transplantation direct · 2026Article
- Salvianolic Acid B Preserves Myocardial Viability and Extends the Preservation Window of Mouse Hearts During Static Cold Storage.Pharmaceuticals (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionMachine perfusion (MP) technology may reduce the incidence of biliary complications (BCs) by reducing ischemia-reperfusion injury. This meta-analysis aimed to compare the effects of MP and static cold storage (SCS) on the incidence of BCs, nonanastomotic stricture (NAS), and anastomotic stricture (AS) after liver transplantation.
methodsRandomized controlled trials (RCTs) comparing the effects of MP versus SCS on BCs, NAS, or AS after liver transplantation were included for the systematic review in October 2024. Random-effects models were used to perform pooled analyses to calculate risk ratios (RRs) with 95% confidence intervals (CIs).
resultsA total of 9 RCTs including 6 hypothermic oxygenate perfusion (HOPE) and 3 normothermic MP (NMP) were eligible for inclusion. Compared with SCS, MP technology seemed to reduce the incidence of BCs (HOPE: RR 0.77, 95% CI 0.62-0.97, P = 0.03; NMP: RR 0.67, 95% CI 0.44-1.00, P = 0.05). In addition, MP technology could explicitly reduce NAS incidence (HOPE: RR 0.40, 95% CI 0.19-0.84, P = 0.01; NMP: RR 0.39, 95% CI 0.19-0.83, P = 0.01). However, MP technology was likely unable to reduce the incidence of AS (HOPE: RR 0.89, 95% CI 0.63-1.26, P = 0.51; NMP: RR 0.99, 95% CI 0.53-1.85, P = 0.99). DISCUSSION: This meta-analysis confirmed that MP technology could reduce the incidence of NAS, which might further lead to a reduction in the incidence of BCs. However, it did not seem to improve AS incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.