SynthesisDigestive diseases and sciences2026
Prophylactic Clip Closure for the Prevention of Delayed Bleeding After EMR of Proximal Large Nonpedunculated Colorectal Polyps: Updated Meta-Analysis of Randomized Controlled Trials.
Synthesis in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Efficacy of prophylactic hemoclip placement for preventing delayed post-polypectomy bleeding in nonpedunculated colorectal lesions: updated meta-analysis and trial sequential analysis of randomized controlled trials.Surgical endoscopy · 2026Review
- Divergent Efficacy of Prophylactic Clipping: Gaps Between Expert Centers and Real‑World Practice.Digestive diseases and sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsClinically significant post-endoscopic mucosal resection bleeding (CSPEB) is one of the most common adverse events after EMR. In this meta-analysis, we evaluated the efficacy of prophylactic clipping after EMR of proximal, large (≥ 20 mm) nonpedunculated colon polyps.
methodsWe reviewed several databases from inception to September 19, 2025. Outcomes of interest were CSPEB, perforation, post-polypectomy syndrome, and abdominal pain. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a random effects model. Subgroup analyses were performed based on trials conducted in specialized/high-volume tertiary referral settings vs mixed practice settings (including community and nonacademic hospitals).
resultsThere was no significant difference in risk of CSPEB between the groups RR, 0.59(95% CI 0.28, 1.23), τ
conclusionIn conclusion, this study demonstrates that prophylactic clip closure after EMR of proximal large nonpedunculated colorectal polyps did not present a statistically significant reduction in CSPEB. However, prophylactic clipping was associated with reduced CSPEB in trials conducted in specialized, high-volume tertiary referral settings, whereas trials conducted in mixed or community-based settings have not demonstrated a similar benefit. Additional randomized controlled trials with standardized reporting of operator experience, center volume, and closure success are needed to clarify effectiveness across broader practice settings.
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Registered trials
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