Evidence map›Paper›PMID 41604049›Full record

ArticleMolecular biology reports2026

Evaluation of cervical healing in a rat model using alginate hydrogel embedded with platelet-rich plasma.

Elham Ahmadi, Mahya Soleymani Mehranjani, Arya Afrooghe, Anoosheh Zargar, Laleh Vahedi Larijani, Sedigheh Hantoushzadeh, Maryam Kazemi, Masoumeh Majidi Zolbin

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Elham Ahmadi *Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mahya Soleymani Mehranjani *Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Arya AfroogheExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Anoosheh ZargarIranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Laleh Vahedi LarijaniDepartment of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Sedigheh HantoushzadehVali-E-Asr Reproductive Health Research Center, Family Health Research InstituteTehran University of Medical Sciences, Tehran, Iran.
Maryam KazemiVali-E-Asr Reproductive Health Research Center, Family Health Research InstituteTehran University of Medical Sciences, Tehran, Iran.
Masoumeh Majidi ZolbinIranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran. Masoumeh.majidizolbin@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExternal damage is a significant and treatable cause of cervical insufficiency (CI). This study evaluates a controlled-release drug delivery system combining platelet-rich plasma (PRP) with alginate hydrogel (Alg-PRP) to enhance cervical healing in a rat model.

methodsForty female Wistar rats were assigned to four groups (n = 10): Alg-PRP, PRP, PBS, and healthy control. Cervical injury was induced, and treatments were administered accordingly. Cervical regeneration was assessed using qRT-PCR, histopathology, and immunohistochemistry (IHC). Functional outcomes, including pregnancy rate and number of pups, were also analyzed.

resultsAlg-PRP hydrogel exhibited a porous structure, minimal toxicity, and sustained growth factor release. VEGF expression was significantly higher in the Alg-PRP group (p < 0.001), while MMP9 and TGF-β expression were reduced (p < 0.0001, p < 0.001). Collagen I and III levels were lower (p < 0.001, p < 0.05). Masson's Trichrome staining confirmed reduced fibrosis (p < 0.01). IHC demonstrated increased epithelial thickness, proliferation (p < 0.001, p < 0.0001), and angiogenesis (p < 0.01), alongside decreased fibrosis markers (p < 0.0001). The Alg-PRP group had the highest pregnancy rate (100%) and greater pup numbers.

conclusionAlg-PRP hydrogel significantly enhances cervical healing and reproductive outcomes, highlighting its potential as a novel therapeutic for cervical injuries.

Indexed as

AlginatesCervix UteriHydrogelsPlatelet-Rich PlasmaWound HealingAnimalsDisease Models, AnimalFemalePregnancyRatsRats, WistarRegenerationAlginatesHydrogelsAlginate hydrogelCervixPlatelet-rich plasma (PRP)

Identifiers

PMID41604049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.