ArticleFish physiology and biochemistry2026
Grna knockout resists HFD-induced obesity and leads to impaired liver development in zebrafish.
Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Progranulin (PGRN) is a cysteine-rich secreted protein that is expressed in epithelial cells, immune cells, neurons, and adipocytes. It was first identified for its growth factor-like properties and is involved in early embryogenesis and tissue remodelling, acting as an anti-inflammatory molecule. Recently, PGRN was recognized as an adipokine related to obesity and insulin resistance, revealing its metabolic function. In zebrafish, the homologous gene most similar to the human PGRN gene is grna (granulin a). In this study, we used previously obtained grna knockout (KO) zebrafish to investigate the role of grna in obesity resistance and liver development. To explore the role of grna in obesity, grna
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