Evidence map›Paper›PMID 41604026›Full record

ArticleMolecular biology reports2026

Genome-wide analysis of HMA gene family in Chrysanthemum indicum and positive role of CiHMA5 in cd tolerance.

Kaiyuan Zhang, Chuyi Chen, Shuguang Liu, Shengyan Chen, Xingyu Ni, Liran Yue, Miao He

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kaiyuan Zhang *College of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China.
Chuyi Chen *College of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China.
Shuguang LiuCollege of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China.
Shengyan ChenCollege of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China.
Xingyu NiCollege of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China.
Liran YueCollege of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China. ylr2008@nefu.edu.cn.
Miao HeCollege of Landscape Architecture, Northeast Forestry University, Harbin, Heilongjiang, 150006, People's Republic of China. hemiao@nefu.edu.cn.

Funding

Natural Science Foundation of Heilongjiang Province No. LH2021C018
6 · The paper itself

Abstract

backgroundSoil contamination with Cadmium (Cd) is one of the major environmental issues facing the world, which poses a tremendous threat to plant growth. Heavy-metal ATPase (HMA), essential to regulate plants' metal homeostasis, has been extensively identified in abundant plant species. However, the HMA gene family members in Chrysanthemum indicum have not been identified. METHODS AND

resultsIn this study, we identified 10 CiHMAs and classified them into three subfamilies: I, II, and III. Transcriptome and qRT-PCR analyses demonstrated significant induction of CiHMA5 expression under Cd stress. CiHMA5 is situated in the chloroplast and cell membrane. Heterologous expression of CiHMA5 in Arabidopsis thaliana exhibits a Cd-tolerant phenotype with diminished Cd accumulation as well as enhanced antioxidant enzyme activity. Furthermore, CiHMA5 transgenic C. indicum plants also conferred a Cd-tolerant phenotype and lower Cd content, accompanied by higher transfer coefficients in shoots and leaves than wild-type (WT). CONLUSION: These findings established a theoretical groundwork for further delve into the role and regulatory mechanism of CiHMAs in Chrysanthemum under Cd stress.

Indexed as

Adenosine TriphosphatasesCadmiumChrysanthemumArabidopsisGene Expression Regulation, PlantMultigene FamilyPhylogenyPlant ProteinsPlants, Genetically ModifiedStress, PhysiologicalAdenosine TriphosphatasesCadmiumPlant ProteinsCdChrysanthemum indicumCiHMA5Heavy metal ATPaseHMA

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.