Evidence map›Paper›PMID 41603998›Full record

ArticleJournal of gastrointestinal cancer2026

Prognostic and Diagnostic Value of Serum Bile Acid Profiles in Pancreatic Cancer: a Retrospective Multicenter Cohort Study.

Chang Liu, Henan Qin, Zeming Wu, Jiwei Liu, Minjie Wang, Jinpeng Yao, Dong Shang, Peiyuan Yin

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chang LiuInstitute of Integrative Medicine, Dalian Medical University, Dalian, China.
Henan QinDepartment of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Zeming WuiPhenome Biotechnology (Yun Pu Kang) Inc., Dalian, China.
Jiwei LiuDepartment of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Minjie WangDepartment of Clinical Laboratory, the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Jinpeng YaoDepartment of Ultrasound, the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Dong ShangInstitute of Integrative Medicine, Dalian Medical University, Dalian, China.
Peiyuan YinInstitute of Integrative Medicine, Dalian Medical University, Dalian, China. yinpeiyuan@dmu.edu.cn.

Funding

key research and development project of Liaoning Province No.2018225054National Key Research and Development Program of China No. 2018YFE0195200National Natural Science Foundation of China No. 81873156
6 · The paper itself

Abstract

purposeBile acids (BAs) are important molecules in the carcinogenesis of pancreatic cancer (PC). The BA profile in pancreatic diseases and its role in PC remain unclear.

methodsThe concentrations of 63 BAs in serum were measured in a total of 421 participants from three medical centers using targeted metabolomics. The concentrations of seven common types of BAs in serum were determined and compared. The least absolute shrinkage and selection operator algorithm analysis was used to confirm the independent predictors and build a metabolite panel for prediction and discrimination.

resultsA panel of two BA metabolites DCA and ω-MCA showed high diagnostic performance for PC versus healthy controls with an AUC of 0.914 (95% CI 0.873-0.956) in the validation cohort and achieved a 94.20% positive rate in the validation cohort. This diagnostic panel correlated with advanced clinical stage (p = 0.006) and poorer overall survival (HR = 3.11, 95% CI 0.79-12.23, p = 0.006). Importantly, biliary obstruction altered total BA concentrations (2.4-fold increase, p < 0.001) but did not change BA compositional proportions (p > 0.05). Additionally, ω-MCA, GCA-3S, GCDCA-3S, UDCA, and secondary BAs may distinguish PC from pancreatic benign tumors. GLCA was able to differentiate PC from pancreatic premalignant lesions. TLCA, 3-oxoLCA, and NorCA can effectively separate PC from chronic pancreatitis.

conclusionBAs are potential diagnostic and prognostic biomarkers for PC, which may also be helpful in differentiating pancreatic diseases.

Indexed as

Bile Acids and SaltsBiomarkers, TumorPancreatic NeoplasmsAdultAgedCase-Control StudiesFemaleHumansMaleMetabolomicsMiddle AgedPrognosisRetrospective StudiesBile Acids and SaltsBiomarkers, TumorBile acidBiomarkerLC–MS/MSPancreatic cancerSerum

Identifiers

PMID41603998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.