Evidence map›Paper›PMID 41603978›Full record

SynthesisArchives of orthopaedic and trauma surgery2026

The role of the gastrocnemius flap in implant retention strategies for acute periprosthetic joint infection following total knee arthroplasty: a systematic review.

Daniele Grassa, Guido Bocchino, Cesare Stefanelli, Giacomo Capece, Rocco Maria Comodo, Alessandro El Motassime, Riccardo Totti, Giulio Maccauro, Raffaele Vitiello

Abstract readSystematic ReviewReview
In one paragraph

Synthesis in Archives of orthopaedic and trauma surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniele GrassaDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy. dr.danielegrassa@gmail.com.
Guido BocchinoDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy. guido.bocchino01@icatt.it.
Cesare StefanelliDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.
Giacomo CapeceDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.
Rocco Maria ComodoDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.
Alessandro El MotassimeDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.
Riccardo TottiDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.
Giulio MaccauroDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.
Raffaele VitielloDepartment of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, Roma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute periprosthetic joint infection (PJI) represents a major cause of early failure following total knee arthroplasty (TKA). In selected cases, implant retention strategies such as debridement, antibiotics, and implant retention (DAIR), including modified techniques such as debridement, antibiotic pearls, and retention of the implant (DAPRI), may be considered. However, the success of these approaches is strongly influenced by the condition of the surrounding soft tissues. In the presence of compromised or tenuous wound conditions, soft tissue reconstruction may play a critical adjunctive role. This review aims to evaluate the role of the gastrocnemius flap as an adjunct to implant retention strategies in the management of acute PJI following TKA.

methodsA systematic review was conducted in accordance with PRISMA guidelines. After screening 27 studies, five retrospective case series met the inclusion criteria, comprising a total of 73 patients with a mean follow-up of 48.7 months.

resultsThe medial gastrocnemius flap was the most used technique, accounting for approximately 70% of cases. Infection clearance rates ranged from 66% to 77%, while prosthesis retention was achieved in nearly 79% of patients. Gastrocnemius flap coverage was applied in conjunction with different PJI treatment strategies, including staged revision procedures and implant retention approaches. Early flap application, particularly when combined with debridement and implant retention in the presence of compromised soft tissues, was associated with improved wound healing and limb salvage, although the level of evidence remains limited.

conclusionsGastrocnemius flap reconstruction appears to be a useful adjunct in selected patients undergoing implant retention strategies for acute PJI following TKA, particularly in the presence of compromised soft tissue conditions. Nevertheless, the current evidence is based on low-level, non-comparative studies, and definitive conclusions regarding its routine or preventive use cannot be drawn. Further prospective and comparative studies are required to better define indications, timing, and expected outcomes.

Indexed as

Arthroplasty, Replacement, KneeKnee ProsthesisMuscle, SkeletalProsthesis-Related InfectionsProsthesis RetentionSurgical FlapsDebridementHumansAcute infectionDAIRGastrocnemius flapImplant retentionJoint arthroplastyPeriprosthetic joint infectionSoft tissue reconstructionSystematic reviewTotal knee arthroplasty

Identifiers

PMID41603978
PMCPMC12852200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.