ArticleExtremophiles : life under extreme conditions2026
Exploring Marinilactibacillus sp from Lake Urmia as a novel halophilic source of antibacterial bioactive compounds.
Article in Extremophiles : life under extreme conditions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Isolation of microbial species from extreme environments represents a promising strategy for discovering novel antibacterial compounds. In this study, halophilic bacteria isolated from the water and sediments of hypersaline Lake Urmia were screened for antibacterial activity. Molecular identification based on PCR amplification and 16S rRNA gene sequencing confirmed the isolate as a Marinilactibacillus strain closely related to M. piezotolerans. This strain exhibited strong inhibitory effects against Staphylococcus aureus (MIC 25 µg·mL⁻1), Escherichia coli (MIC 200 µg·mL⁻1), and five methicillin-resistant S. aureus (MRSA) strains (MIC 25–50 µg·mL⁻1; inhibition zones 13–18 mm). Gas chromatography–mass spectrometry analysis revealed several bioactive secondary metabolites, including Di-n-octyl phthalate, Diisooctyl phthalate, and Bis(2-ethylhexyl) phthalate, which may contribute to the observed antibacterial activity. This is the first report describing a bioactive Marinilactibacillus isolate from Lake Urmia sediments, emphasizing hypersaline environments as valuable reservoirs of halophilic bacteria with potential for producing alternative antimicrobial agents.
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