Evidence map›Paper›PMID 41603967›Full record

ArticleNeurosurgical review2026

Safety and efficacy of sEEG-guided resective surgery in patients with MRI-negative drug-resistant epilepsy.

Xavier Schumacher, Valerio Frazzini, Claude Adam, Sophie Dupont, Franck Bielle, Alice Guesdon, Marie Mere, Vi-Huong Nguyen-Michel, Vincent Navarro, Bertrand Mathon

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In one paragraph

Article in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xavier SchumacherDepartment of Neurosurgery, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Valerio FrazziniDepartment of Neurology, Epileptology and EEG Unit, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Claude AdamDepartment of Neurology, Epileptology and EEG Unit, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Sophie DupontDepartment of Neurology, Epileptology and EEG Unit, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Franck BielleParis Brain Institute, ICM, INSERM, CNRS, Sorbonne Université, 75013, Paris, France.
Alice GuesdonDepartment of Psychiatry, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Marie MereDepartment of Neurology, Epileptology and EEG Unit, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Vi-Huong Nguyen-MichelDepartment of Neurology, Epileptology and EEG Unit, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Vincent NavarroDepartment of Neurology, Epileptology and EEG Unit, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France.
Bertrand MathonDepartment of Neurosurgery, APHP, La Pitié-Salpêtrière Hospital, Sorbonne Université, 75013, Paris, France. bertrand.mathon@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the long-term efficacy and safety of stereo-electroencephalography (sEEG)-guided surgical resection in patients with MRI-negative, drug-resistant focal epilepsy and to identify predictors of favorable seizure outcomes.

methodsWe conducted a retrospective cohort study of 107 patients who underwent sEEG-guided resective epilepsy surgery at a tertiary neurosurgical center. The inclusion criteria were normal brain MRI (MRI-negative), drug-resistant focal epilepsy, and a minimum postoperative follow-up of one year.

resultsThe temporal lobe was the most commonly resected site (66.2%), followed by the frontal lobe (24.8%). The mean postoperative follow-up period was 8.2 ± 7.0 years. Complete seizure freedom (ILAE class 1) was achieved in 46.7% of the patients, and 54.2% had favorable outcomes (ILAE class 1 or 2). Clinical improvement was observed in 88.3% of patients, and reduction or discontinuation of antiseizure medications was observed in 61.7% of patients. Major complications (persistent motor deficits, disabling visual defects) occurred in 2.8% of cases. Neuropsychological function remained stable in 69.3%, improved in 14.9%, and worsened in 15.8% of patients. Quality of life improved significantly in 79.4% of the patients, and 70.1% resumed or maintained employment. A longer duration of sEEG monitoring was independently associated with seizure freedom (p = 0.008; OR, 1.2; 95%CI [1.04–1.3]). Histopathological analysis revealed abnormal findings in 90% of the resected specimens.

conclusionsEEG-guided surgery in MRI-negative drug-resistant epilepsy provides substantial seizure control and significant improvements in quality of life, demonstrating a favorable risk–benefit ratio. Extended intracranial monitoring is a key predictor of surgical success.

Indexed as

Drug Resistant EpilepsyElectroencephalographyNeurosurgical ProceduresAdolescentAdultChildFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesStereotaxic TechniquesTreatment OutcomeYoung AdultCryptogenic epilepsyDrug-resistant epilepsyEpilepsy surgeryIntracranial EEGMRI-negative epilepsyNon-lesional epilepsy

Identifiers

PMID41603967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.