Evidence map›Paper›PMID 41603959›Full record

ArticleAnalytical and bioanalytical chemistry2026

Relevance analysis of N-glycan variations in C2C12 cells and mouse serum under simulated microgravity using a quaternary phosphonium hydrazide labeling strategy-based mass spectrometry quantitation approach.

Qian-Ru Ma, Jie-Cheng Lu, Yan-Qing Li, Hong-Jie Lan, Yan Liu, Yu-Fen Zhao

Abstract read
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Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Qian-Ru MaDepartment of Chemistry, Department of Chemical Biology, Fujian Key Laboratory of Chemical Biology (Xiamen University), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P.R. China.
Jie-Cheng LuDepartment of Chemistry, Department of Chemical Biology, Fujian Key Laboratory of Chemical Biology (Xiamen University), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P.R. China.
Yan-Qing LiDepartment of Chemistry, Department of Chemical Biology, Fujian Key Laboratory of Chemical Biology (Xiamen University), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P.R. China.
Hong-Jie LanDepartment of Chemistry, Department of Chemical Biology, Fujian Key Laboratory of Chemical Biology (Xiamen University), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P.R. China.
Yan LiuDepartment of Chemistry, Department of Chemical Biology, Fujian Key Laboratory of Chemical Biology (Xiamen University), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P.R. China. stacyliu@xmu.edu.cn.
Yu-Fen ZhaoDepartment of Chemistry, Department of Chemical Biology, Fujian Key Laboratory of Chemical Biology (Xiamen University), College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P.R. China.

Funding

Ningbo Top Talent Project No. 215-432094250the Natural Science Foundation of Fujian Province of China No. 2023J01017the Space Application System of China Manned Space Program No. KJZ-YY-WSM01the Space Application System of China Manned Space Program No. YYWT-0901-EXP-16
6 · The paper itself

Abstract

Mass spectrometry combined with stable isotope labeling is a powerful technique for detecting disease-related changes in glycosylation patterns and identifying potential biomarkers. However, stable isotope labeling reagents that simultaneously offer high sensitivity, low cost, and stable sialic acid modifications remain scarce. In this study, we developed a convenient and cost-effective microwave-assisted method for synthesizing a stable isotopic quaternary phosphonium hydrazide labeling reagent pair,

Indexed as

HydrazinesMass SpectrometryOrganophosphorus CompoundsPolysaccharidesSpectrometry, Mass, Electrospray IonizationWeightlessnessAnimalsCell LineChromatography, High Pressure LiquidIsotope LabelingMiceReproducibility of ResultsHydrazinesOrganophosphorus CompoundsPolysaccharidesHPLC-ESI-HRMSMuscle atrophyN-GlycomicsPhosphonium hydrazideSimulated microgravityStable isotope relative quantitation

Identifiers

PMID41603959

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.