ArticleJournal of the American Heart Association2026
Chronotype, Life's Essential 8, and Risk of Cardiovascular Disease: A Prospective Cohort Study in UK Biobank.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Rotating Night Shift Work and Risk of Incident Cardiovascular Disease and Mortality by Chronotype: A Prospective Cohort Study in Nurses' Health Study II.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Role of Life's Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants.Journal of global health · 2026Article
- Chronotype and Cardiovascular Disease Risk Factors among Middle-aged and Older Adults: An observational and Mendelian Randomization Study.medRxiv : the preprint server for health sciences · 2026Article
- Circadian control of immune homeostasis in cardiovascular health and disease.Frontiers in immunology · 2026Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with an evening chronotype often experience circadian misalignment, which may disrupt health behaviors and cardiometabolic functions.
methodsWe conducted a prospective study in 322 777 UK Biobank participants aged 39 to 74 years free of known cardiovascular disease (CVD). Chronotype was self-reported using a single representative question. The Life's Essential 8 (LE8) score was calculated from 8 CVD risk factors and ranged from 0 to 100 with higher scores indicating better cardiovascular health. Incident CVD was defined as first myocardial infarction or stroke. Cox proportional hazards models estimated the association between chronotype and CVD risk, adjusted for sociodemographics, shift work, and family history of CVD. We evaluated the role of LE8 in the chronotype-CVD association by decomposing the total effect into natural direct effect (independent of LE8) and natural indirect effect (mediated by LE8).
resultsParticipants with a "definite evening" chronotype were associated with 79% higher prevalence of an overall poor LE8 score (<50 points) compared with "intermediate" type (95% CI, 1.72-1.85). Over a median 13.8 years of follow-up, there were 17 584 incident CVD events (11 091 myocardial infarction; 7214 stroke). The hazard ratio (HR) for total CVD was 1.03 (95% CI, 0.998-1.07) for the "definite morning" and 1.16 (95% CI, 1.10-1.22) for "definite evening" compared with "intermediate" chronotype (
conclusionsOur findings suggest that individuals with an evening chronotype may particularly benefit from interventions targeting CVD risk factors.
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