Evidence map›Paper›PMID 41603544›Full record

Observational studyHuman vaccines & immunotherapeutics2026

The impact of pneumococcal conjugate vaccines on disease epidemiology, serotype distribution, and antimicrobial resistance in children. A 25-year observational study in Athens, Greece (1996-2021).

Vasiliki P Syriopoulou, George L Daikos, Emmanouil I Koutouzis, Elizabeth-Barbara Tatsi, Theano Georgakopoulou, Foteini I Koutouzi, Ageliki Stathi, Kalliopi Spyridopoulou, Anthi Sideri, Anastasios Doudoulakakis and 9 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Case reports in pediatrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Vasiliki P SyriopoulouInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
George L DaikosFirst Department of Medicine, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Emmanouil I KoutouzisInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Elizabeth-Barbara TatsiInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Theano GeorgakopoulouDepartment of Vaccine Preventable Diseases, National Public Health Organization (NPHO), Athens, Greece.
Foteini I KoutouziInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ageliki StathiMicrobiology Department, "Aghia Sophia" Children's Hospital, Athens, Greece.
Kalliopi SpyridopoulouMicrobiology Department, "Aghia Sophia" Children's Hospital, Athens, Greece.
Anthi SideriCentral Laboratories, Hygeia General Hospital, Athens, Greece.
Anastasios DoudoulakakisDepartment of Microbiology, P. & A. Kyriakou Children's Hospital, Athens, Greece.
Georgios KalogerasDepartment of Microbiology, P. & A. Kyriakou Children's Hospital, Athens, Greece.
Theodota LiakopoulouFirst Department of Paediatrics, 'IASO' Children's Hospital, Athens, Greece.
Dimitra-Maria KoukouInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Chara AsimakiPediatric Department, Euroclinic Children's Hospital, Athens, Greece.
Eleni TsapraPediatric Department, Euroclinic Children's Hospital, Athens, Greece.
Evangelia LebessiDepartment of Microbiology, P. & A. Kyriakou Children's Hospital, Athens, Greece.
Levantia ZachariadouMicrobiology Department, "Aghia Sophia" Children's Hospital, Athens, Greece.
Eleni PapadogeorgakiCentral Laboratories, Hygeia General Hospital, Athens, Greece.
Athanasios MichosInfectious Diseases and Chemotherapy Research Laboratory, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug Resistance, BacterialHeptavalent Pneumococcal Conjugate VaccinePneumococcal InfectionsPneumococcal VaccinesStreptococcus pneumoniaeAdolescentAnti-Bacterial AgentsChildChild, PreschoolFemaleGreeceHumansInfantMaleMicrobial Sensitivity TestsRetrospective Studies13-valent pneumococcal vaccineAnti-Bacterial AgentsHeptavalent Pneumococcal Conjugate VaccinePneumococcal VaccinesVaccines, Conjugateantimicrobial susceptibilitychildrenmultidrug resistancepneumococcal diseaseserotypesStreptococcus pneumoniaevaccines

Identifiers

PMID41603544
PMCPMC12854370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.