Evidence map›Paper›PMID 41603488›Full record

ArticlePhysiological reports2026

Extracellular acidity and ATP modulate ion currents in human cumulus cells indicating possible roles as metabolic sensors of the follicular microenvironment.

Andrea Biagini, Rosaria Gentile, Cristina Corbucci, Monica Mariani, Alessandro Favilli, Sandro Gerli, Bernard Fioretti

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea BiaginiDepartment of Medicine and Surgery, University of Perugia, Perugia, Italy.
Rosaria GentileDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.
Cristina CorbucciCentre of Assisted Reproductive Technologies, S. Maria della Misericordia Hospital, Perugia, Italy.
Monica MarianiCentre of Assisted Reproductive Technologies, S. Maria della Misericordia Hospital, Perugia, Italy.
Alessandro FavilliInterdepartmental Laboratory of Reproductive Physiopathology, University of Perugia, Perugia, Italy.
Sandro GerliInterdepartmental Laboratory of Reproductive Physiopathology, University of Perugia, Perugia, Italy.
Bernard FiorettiDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0002-9570-4195

Funding

Ministero delle Imprese e del Made in Italy F/350076/01/X60-VAPORE-CUP B99J24001000005Ministero dell'Università e della Ricerca (MUR) 202294JF88Ministero dell'Università e della Ricerca (MUR) 38-0333-23-DOT1323112-2293
6 · The paper itself

Abstract

Cumulus cells (CCs), derived from granulosa cells, play a key role in supporting oocyte maturation and development through bidirectional communication. However, their electrophysiological properties in humans are poorly defined. Here, we characterized ionic currents and their modulation in primary human CCs obtained from patients undergoing in vitro fertilization. Whole cell patch-clamp recordings identified three electrophysiological sub-populations: CC-type 1, expressing voltage-dependent K

Indexed as

Adenosine TriphosphateCellular MicroenvironmentCumulus CellsOvarian FollicleCalciumCells, CulturedFemaleHumansHydrogen-Ion ConcentrationLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsTRPM Cation ChannelsAdenosine TriphosphateCalciumKCNMA1 protein, humanLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsTRPM5 protein, humanTRPM Cation Channelscumulus cellsfemale fertilityfollicular microenvironmention channelspatch clampreproductive biology

Identifiers

PMID41603488
PMCPMC12849215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.