Evidence map›Paper›PMID 41603468›Full record

ArticleJournal of proteome research2026

A Multiomic Approach Integrating Genomic and Metabolomic Data Highlights Colorectal Cancer Pathways.

Aikaterini Iliou, Elena Chekmeneva, Rui Climaco Pinto, Fotini E Koukouzeli, Yiannis Ntounias, Konstantina Georgakopoulou, Marialena Pouliou, Marios Agelopoulos, Konstantinos K Tsilidis, Marc J Gunter and 6 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The role of NADFrontiers in oncology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Aikaterini IliouDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.ORCID 0000-0002-4644-7284
Elena ChekmenevaNational Phenome Centre, Section of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW 72AZ, U.K.ORCID 0000-0003-1807-2398
Rui Climaco PintoNational Phenome Centre, Section of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW 72AZ, U.K.ORCID 0000-0002-8527-4873
Fotini E KoukouzeliBiomedical Research Foundation of the Academy of Athens (BRFAA), 115 27 Athens, Greece.ORCID 0009-0001-5675-4632
Yiannis NtouniasBiomedical Research Foundation of the Academy of Athens (BRFAA), 115 27 Athens, Greece.
Konstantina GeorgakopoulouBiomedical Research Foundation of the Academy of Athens (BRFAA), 115 27 Athens, Greece.ORCID 0009-0000-5199-5480
Marialena PouliouBiomedical Research Foundation of the Academy of Athens (BRFAA), 115 27 Athens, Greece.
Marios AgelopoulosBiomedical Research Foundation of the Academy of Athens (BRFAA), 115 27 Athens, Greece.
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, U.K.
Marc J GunterDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, U.K.ORCID 0000-0001-5472-6761
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, U.K.ORCID 0000-0002-7511-5684
Julian L GriffinThe Rowett Institute, University of Aberdeen, Aberdeen AB25 2ZD, U.K.
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, U.K.
Apostolos KlinakisBiomedical Research Foundation of the Academy of Athens (BRFAA), 115 27 Athens, Greece.
Emmanuel MikrosDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.ORCID 0000-0002-5984-5169
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, U.K.

Funding

Ceramides as novel drivers of metabolic dysfunction and colorectal cancerU01CA272529 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Mary Christine Playdon, SCOTT A SUMMERS · 2022 to 2026
$4.7M
NCI NIH HHS U01 CA272529
6 · The paper itself

Abstract

Numerous genetic variants have been identified by genome-wide association studies as being associated with colorectal cancer (CRC) risk. Metabolome-wide association analysis was performed for 187 CRC-associated genetic variants using genomic data and untargeted

Indexed as

Colorectal NeoplasmsMetabolomeMetabolomicsCaco-2 CellsFemaleGenome-Wide Association StudyGenomicsHumansMaleMultiomicsPolymorphism, Single Nucleotidecolorectal cancerGWASmetabolomicsmultiomicsRho GTPaseurine

Identifiers

PMID41603468
PMCPMC12887983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.