ArticleJournal of medicinal chemistry2026
Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening.
Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
Academic drug discovery laboratories tend to accumulate collections of compounds with great potential value that merely reside in fridges and freezers. Cross screening these libraries against alternative targets holds significant potential for uncovering novel hits, but in the academic setting compound collections are rarely used, and shared, in this way. We present a short guide for collecting small molecules not being actively pursued in group projects (which we term "idlers") to establish an open compound library. We describe how a diverse subset of this library was screened against a panel of pathogens, with the resulting data made publicly available. We hope to encourage other academic groups to develop and share their own libraries of idlers, thereby maximizing the utility of existing resources, enabling new insights, and catalyzing novel research directions through open science.
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