Evidence map›Paper›PMID 41603382›Full record

ArticleJournal of cellular and molecular medicine2026

Protumorigenic Responses of CEACAM6 in Helicobacter pylori-Infected Gastric Cancer Cells.

Debashish Chakraborty, Indrajit Poirah, Supriya Samal, Smaran Banerjee, Aranya Pal, Chandan Mahish, Subhasis Chattopadhyay, Girija Nandini Kanungo, Pusparaj Samantasinhar, Gautam Nath and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Debashish ChakrabortySchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Indrajit PoirahSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Supriya SamalSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Smaran BanerjeeSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Aranya PalSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Chandan MahishSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Subhasis ChattopadhyaySchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.
Girija Nandini KanungoImmuno Haematology and Blood Transfusion, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Pusparaj SamantasinharForensic Medicine and Toxicology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.
Gautam NathDepartment of Gastroenterology, Acharya Harihar Post Graduate Institute of Cancer, Cuttack, Odisha, India.
Niranjan RoutDigestive Diseases Centre, Beam Diagnostics Building, Cuttack, Odisha, India.
Shivaram Prasad SinghDigestive Diseases Centre, Beam Diagnostics Building, Cuttack, Odisha, India.
Asima BhattacharyyaSchool of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, an OCC of Homi Bhabha National Institute, Khurda, Odisha, India.ORCID https://orcid.org/0000-0001-7292-6644

Funding

DAEGovernment of IndiaNISER
6 · The paper itself

Abstract

Helicobacter pylori poses a significant risk for gastric cancer (GC) development. H. pylori exploits carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) on GC cells (GCCs) to colonise the gastric epithelium. CEACAM1, CEACAM5 and CEACAM6 are known to interact with H. pylori. We explored the role of H. pylori in altering CEACAM levels in GCCs and the paracrine effect of infected GCCs on neighbouring uninfected GCCs and macrophages. H. pylori significantly upregulated CEACAM6. Elevated CEACAM6 in GCCs promoted cell proliferation, cell migration and cell invasion. The effect was further enhanced after infection with H. pylori. Similarly, soluble factors released by CEACAM6-transfected GCCs promoted the tumorigenic potential of uninfected GCCs. Macrophages are crucial for GC development and progression. Therefore, it was intriguing to know how CEACAM6 could influence the polarisation of macrophages during H. pylori infection. To study this, we co-cultured macrophages with either the empty vector or CEACAM6-expressing GCCs and found that H. pylori infection increased the M2 polarisation of macrophages co-incubated with CEACAM6-expressing GCCs. In summary, CEACAM6 was found to promote GC aggressiveness and alter macrophage polarisation. This information could be harnessed to develop future therapeutics for targeting GC.

Indexed as

Antigens, CDCell Adhesion MoleculesHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationGastric MucosaGPI-Linked ProteinsHumansMacrophagesAntigens, CDCEACAM6 protein, humanCell Adhesion MoleculesGPI-Linked Proteinscarcinoembryonic antigen‐related cell adhesion moleculesgastric cancerHelicobacter pylorimacrophageperipheral blood mononuclear cellssoluble factors

Identifiers

PMID41603382
PMCPMC12848906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.