ArticleJournal of Alzheimer's disease : JAD2026
Selective vulnerability of human synapses to soluble tau oligomers.
Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mechanistic insights into the synaptic damage-repair and regeneration processes in neurodegenerative Alzheimer's disease: phytochemicals as neuroprotective agents.Frontiers in synaptic neuroscience · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
BackgroundSoluble tau oligomers (tauO) are early, synaptotoxic drivers of dysfunction in tauopathies. While selective vulnerability is well documented at the cellular level, emerging evidence suggests that synaptic subtypes may differ in their susceptibility to tau pathology. Still, the key factors that shape synaptic vulnerability to toxic tauO, particularly in humans, remain poorly understood.ObjectiveTo define the synaptic compartments and subtypes most vulnerable to tauO and identify molecular correlates underlying this susceptibility.MethodsSynaptosomes were isolated from cognitively normal human autopsy specimens and acutely challenged with preformed recombinant tauO. Flow cytometry with multiplexed immunophenotyping resolved tauO engagement across intact pre- and postsynaptic compartments and excitatory versus inhibitory subtypes. Functional effects were assessed by microtransplanting synaptic membranes into
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