ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5-Dependent RNA Demethylation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Immunoengineering in the field of tendon and bone regeneration: immunomodulatory biomaterials, delivery platforms, and preclinical models for chronic diseases.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
Adult tendon injuries pose a major clinical challenge due to limited self-repair capacity, resulting in suboptimal regeneration. Although tendon stem/progenitor cells (TSPCs) are pivotal for tendon engineering, achieving microstructure and functional regeneration remains challenging. Organoids boost tissue regeneration post-transplantation in multiple organs. however, tendon-specific organoids with stable phenotype and regenerative capacity are still lacking. Since fetal tendons possess strong regenerative capabilities, the construction of fetal-like tendon organoids is crucial for promoting tendon regeneration. In this study, we generated fetal-like tendon organoids (FT organoids) from adult TSPCs using a serum-free 3D culture system that recapitulated the in vivo microenvironment. These organoids exhibited robust phenotypic restoration and enhanced tenogenic potential, with a gene expression profile resembling fetal tendon development. Notably, transplantation experiments demonstrated functional regeneration of organized tendon collagen matrices in vivo. Furthermore, the mRNA demethylase ALKBH5 plays a critical role in activating key regulatory networks for tendon regeneration via the TGF-β signaling pathway. These findings provided compelling evidence that FT organoids represent a promising strategy for tendon collagen microstructure regeneration and highlights their promising clinical translation potential.
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