Evidence map›Paper›PMID 41603077›Full record

ArticleJournal of comparative effectiveness research2026

Indirect comparisons of tucatinib in combination with trastuzumab for patients with previously treated HER2-positive metastatic colorectal cancer.

Claire Watkins, Cyndy Simon, Peter Martin, Regina Leadley, Gabrielle Redhead, Edward Neuberger, Karen Bartley

Abstract readComparative Study
In one paragraph

Article in Journal of comparative effectiveness research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claire WatkinsClarostat Consulting, Bollington, UK.ORCID 0000-001-6475-2795
Cyndy SimonPfizer Limited, Sandwich, UK.
Peter MartinPfizer Limited, Sandwich, UK.
Regina LeadleyMtech Access, Bicester, UK.
Gabrielle RedheadMtech Access, Bicester, UK.
Edward NeubergerPfizer Inc, South San Francisco, CA 94080, USA.
Karen BartleyPfizer Inc, South San Francisco, CA 94080, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsOxazolesPyridinesQuinazolinesTrastuzumabAgedDrug CombinationsErb-b2 Receptor Tyrosine KinasesFemaleHumansMaleMiddle AgedMulticenter Studies as TopicPhenylurea CompoundsProgression-Free SurvivalDrug CombinationsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesOxazolesPhenylurea CompoundsPyridinesPyrrolidinesQuinazolinesThymineTrastuzumabTrifluridinetrifluridine tipiracil drug combinationtucatinibcolorectal cancercomparative effectivenessmatching-adjusted indirect comparisonsurvival

Identifiers

PMID41603077
PMCPMC12884334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.