Evidence map›Paper›PMID 41603014›Full record

ReviewFrontiers in neurology2025

Hyperpolarization-activated cyclic nucleotide-gated channels and epilepsy: genetics, circuits, and treatments.

Ming-Shan Cai, Peng Liao, Zhen-Liang Hu, Yun Li, Jia-Xing Zhao, Liang Jin, Hong-Wei Wang, Yong-Jun Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ming-Shan CaiDepartment of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Peng LiaoDepartment of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Zhen-Liang HuDepartment of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Yun LiDepartment of Brain Function and Neuroelectrophysiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Jia-Xing ZhaoDepartment of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Liang JinDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Hong-Wei WangDepartment of Neurology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Yong-Jun ChenDepartment of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a common chronic disorder of the central nervous system characterized by recurrent seizures arising from abnormal, hypersynchronous neuronal activity; its pathogenesis is complex and remains incompletely understood. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are a family of voltage-gated ion channels that mediate the hyperpolarization-activated cation current (I

Indexed as

circuitsepilepsygenetic mechanismsHCN channelstargeted therapies

Identifiers

PMID41603014
PMCPMC12833324

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.