ArticleFrontiers in neurology2025
Impact of the drip-and-ship model on the treatment of acute ischemic stroke in relation to distance from the thrombectomy center.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Intravenous thrombolysis use before interhospital transfer for thrombectomy: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The drip-and-ship model is a common practice for patients with ischemic stroke due to large-vessel occlusion (LVO), providing initial diagnostics and thrombolysis in transition to endovascular treatment (EVT). However, hospital transfer results in treatment delays for patients requiring EVT, potentially affecting outcomes. We sought to explore the association between distance from residence and time intervals to admission with clinical outcomes after EVT. Methods: In this monocentric retrospective cohort study, patients with acute ischemic stroke due to LVO who underwent EVT at Frankfurt University Hospital between 2017 and 2023 were analyzed. Patients were grouped according to direct-to-center (DC) or drip-and-ship (DS) admission. Clinical outcome parameters included patient global disability after 90 days as measured by the modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) score improvements analyzed in relation to geographical distance and time metrics. A subgroup analysis based on the distance from residence in 10 km intervals was added. Results: A total of 334 patients were included. Of these, 41.9% were DC admissions and 58.1% DS were admissions. Distances from home to center were shorter for DC patients (11.1 km vs. 36.4 km, Conclusion: Proximity of residence to a thrombectomy center may be advantageous for stroke patients, most likely in association with direct pre-hospital transfers. Distances above 30 km more frequently led to drip-and-ship, which may facilitate care through early diagnostics as, signified by a reduction in the relative time delay to flow restoration.
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