ArticleFrontiers in neurology2025
High-stimulation-rate ABR predicts persistent auditory pathway dysfunction in neonates with severe hyperbilirubinemia: a 6-month longitudinal study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to analyze high-stimulation-rate auditory brainstem response (ABR) outcomes in neonates diagnosed with hyperbilirubinemia (NH) and assess its clinical relevance. Methods: This study utilized a prospective longitudinal cohort design. It included ABR tests conducted at 11.1 and 51.1 stimulations per second, alongside serum total bilirubin (TSB) measurements for 28 neonates (56 ears) with severe NH, 28 neonates (56 ears) with mild-to-moderate NH, and 28 neonates (56 ears) from a healthy control group (CG) during their hospital stay. We compared the differences among these groups. Additionally, ABR tests at both high and low stimulation rates were administered to neonates with severe and mild-to-moderate NH at ages 3 and 6 months to compare both inter-group and intra-group variations. Results: (1) During hospitalization, interpeak latency (IPL) differences between waves I and V (ΔIPL I-V) at high (51.1 stimulations per second) and low (11.1 stimulations per second) stimulation rates showed that the severe NH group exhibited longer ΔIPL I-V compared to the healthy CG ( Conclusion: High-stimulation-rate ABR is a potent tool for detecting auditory deficits in neonates with NH. Neonates with severe NH exhibit persistent auditory abnormalities, whereas those with mild-to-moderate conditions display only transient alterations. These findings underscore the value of high-stimulation-rate ABR in the early identification of neonates at high risk, recommending its incorporation into routine follow-up protocols for those with severe NH.
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