ArticleFrontiers in neurology2025
Disrupted modular and hub topology in right temporal lobe epilepsy: a multimodal MRI network analysis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Right temporal lobe epilepsy (rTLE) is associated with disruptions in functional brain networks and structural connectivity, yet underlying mechanisms remain unclear. This study investigated the alterations in modular interactions, connector hub (CH) topology, and related structural changes in rTLE patients. It included 30 rTLE patients and 30 matched healthy controls (HCs), all of whom underwent resting-state functional MRI (rs-fMRI), diffusion-weighted imaging (DWI), and volumetric MRI (vMRI). Functional networks were analyzed by assessing modular interactions, functional connectivity (FC), and CH topological properties. White matter microstructural differences were examined using tract-based spatial statistics (TBSS), while cortical morphometry was evaluated in key CH regions. Compared with HCs, rTLE patients showed reduced modularity (Q), small-world index (
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