Evidence map›Paper›PMID 41602975›Full record

ArticleFrontiers in neurology2025

Multiple sclerosis and the risk of dementia: a real-world, nationwide cohort study.

Ting-An Chen, Sung-Tao Li, Wu-Chien Chien, Chi-Hsiang Chung, Fang-Jung Wan, Ta-Chuan Yeh, Yi-Wei Yeh, Nian-Sheng Tzeng

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In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ting-An ChenDepartment of Psychiatry, Tri-Service General Hospital and School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Sung-Tao LiDepartment of Psychiatry, Tri-Service General Hospital and School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Wu-Chien ChienDepartment of Medical Research, Tri-Service General Hospital and National Defense Medical University, Taipei, Taiwan.
Chi-Hsiang ChungDepartment of Medical Research, Tri-Service General Hospital and National Defense Medical University, Taipei, Taiwan.
Fang-Jung WanDepartment of Psychiatry, Tri-Service General Hospital and School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Ta-Chuan YehDepartment of Psychiatry, Tri-Service General Hospital and School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Yi-Wei YehDepartment of Psychiatry, Tri-Service General Hospital and School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.
Nian-Sheng TzengDepartment of Psychiatry, Tri-Service General Hospital and School of Medicine, College of Medicine, National Defense Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that often causes cognitive impairment. This study aimed to investigate the association between MS and the risk of dementia in a large, nationwide Taiwanese cohort and to examine the potential impact of Disease-modifying drugs (DMDs) on the dementia incidences. Methods: We conducted a population-based cohort study using Taiwan's National Health Insurance Research Database (NHIRD) between 2000 and 2015. Adults aged ≥20 years with a diagnosis of MS ( Results: During the follow-up, the cumulative incidence of dementia was higher in the MS cohort (739.97 per 100,000 person-years) than in the controls (343.95 per 100,000 person-years; log-rank Conclusion: MS is an independent and potent risk factor for dementia in the Taiwanese population, from the NHIRD records. The findings underscore the importance of the early cognitive monitoring, the comprehensive comorbidity management, and the optimal pharmacologic intervention. The DMD usage may be associated with a reduced risk of dementia, thereby warranting further prospective investigation.

Indexed as

dementiadisease-modifying drugsmultiple sclerosisNational Health Insurance Research Databasenationwide cohort study

Identifiers

PMID41602975
PMCPMC12832492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.