ArticleiScience2026
Cellular and molecular profiling of collagenous gastritis implicates pathogenic CD4
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Article
- Case Report: Collagenous gastritis presenting with refractory dyspepsia and diffuse gastric atrophic-appearing changes.Frontiers in medicine · 2026Article
- Collagenous gastritis: current understanding of a rare immune-mediated gastropathy across pediatric and adult phenotypes-from pathogenesis to therapeutic strategies.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collagenous gastritis (CG) is a rare disease characterized by thick bands of subepithelial collagen within the stomach that presents with symptoms ranging from anemia to vomiting. Its etiology is poorly understood, and currently, there are no well-defined effective treatment options. We collected gastric and duodenal biopsies from seven patients with CG and several matched controls. Flow cytometry, histopathology, and single-cell RNA-seq (scRNA-seq) and T cell receptor (TCR)-sequencing were performed on samples to understand immune mechanisms underlying CG. Patients with CG had reduced parietal cells and enhance expression of collagen genes by fibroblasts. We identified a population of activated/exhausted lymphocytes, with increased CD4:CD8 ratios and decreased tissue-resident T cells in patients with CG compared to controls. We identified potential therapeutic targets, including integrin α4 expression (
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Registered trials
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